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已发表论文
熊去氧胆酸（UDCA）的药理活性、生物合成及结构修饰研究进展：综述
Authors Li P, Wang J, Hao H, Chen X, He X, Shao Q
Received 31 July 2025
Accepted for publication 27 November 2025
Published 5 December 2025 Volume 2025:19 Pages 10775—10810
DOI https://doi.org/10.2147/DDDT.S557300
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Anastasios Lymperopoulos
Ping Li,1 Jia Wang,2 Han Hao,2 Xufei Chen,2 Xirui He,3 Qing Shao1
1Pharmacy Department, Xi’an Mental Health Center, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Key Laboratory of Resource Biology and Modern Biotechnology in Western China, College of Life Science, Northwest University, Xi’an, Shaanxi, 710069, People’s Republic of China; 3School of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai, Guangdong, 519041, People’s Republic of China
Correspondence: Qing Shao, Pharmacy Department, Xi’an Mental Health Center, Chang’an District, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 13891842435, Email xajwshaoqing@163.com
Abstract: UDCA is a natural steroid in bear bile, which has important medicinal value. It is used to treat hepatobiliary diseases in clinic. Due to its unique molecular skeleton, UDCA has a wide range of biological activities, special target and low toxicity, and is considered to be a powerful structural mother nucleus, which has attracted more and more researchers’ attention and become the focus of attention again. So far, UDCA derivatives with diverse structures have been designed and their biological activities have been extensively studied. In this paper, the pharmacological activities, biosynthesis and structural modification of UDCA were systematically discussed. It is believed that with the deepening of research, more UDCA derivatives with better medicinal properties will become drugs and better serve human health.
Keywords: ursodeoxycholic acid, pharmacological activities, biosynthesis, structural modification
1Pharmacy Department, Xi’an Mental Health Center, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Key Laboratory of Resource Biology and Modern Biotechnology in Western China, College of Life Science, Northwest University, Xi’an, Shaanxi, 710069, People’s Republic of China; 3School of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai, Guangdong, 519041, People’s Republic of China
Correspondence: Qing Shao, Pharmacy Department, Xi’an Mental Health Center, Chang’an District, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 13891842435, Email xajwshaoqing@163.com
Abstract: UDCA is a natural steroid in bear bile, which has important medicinal value. It is used to treat hepatobiliary diseases in clinic. Due to its unique molecular skeleton, UDCA has a wide range of biological activities, special target and low toxicity, and is considered to be a powerful structural mother nucleus, which has attracted more and more researchers’ attention and become the focus of attention again. So far, UDCA derivatives with diverse structures have been designed and their biological activities have been extensively studied. In this paper, the pharmacological activities, biosynthesis and structural modification of UDCA were systematically discussed. It is believed that with the deepening of research, more UDCA derivatives with better medicinal properties will become drugs and better serve human health.
Keywords: ursodeoxycholic acid, pharmacological activities, biosynthesis, structural modification