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已发表论文
脂质体布比卡因关节囊周神经组阻滞对老年髋部骨折患者术后反弹痛的影响：一项随机对照试验
Authors Wang Q , Wang J, Liu Y, Dai Z, Wang Y, Xia X, Li Y
Received 27 August 2025
Accepted for publication 2 December 2025
Published 5 December 2025 Volume 2025:19 Pages 10811—10820
DOI https://doi.org/10.2147/DDDT.S562733
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Anastasios Lymperopoulos
Qiang Wang,1,* Jiyuan Wang,2,* Yujia Liu,1 Zhen Dai,1 Yan Wang,1 Xiaoqiong Xia,1 Yuanhai Li2
1Anesthesiology Department, The Fourth Affiliated Hospital of Anhui Medical University, ChaoHu, Hefei, People’s Republic of China; 2Anesthesiology Department, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoqiong Xia, Anesthesiology Department, The Fourth Affiliated Hospital of Anhui Medical University, ChaoHu, Hefei, Anhui Province, 238000, People’s Republic of China, Tel +8613966386669, Email xxq2366833@sina.com Yuanhai Li, Anesthesiology Department, the First Affiliated Hospital of AnHui Medical University, Hefei, 230000, People’s Republic of China, Tel +8613505697561, Email liyuanhai-1@163.com
Objective: This study aims to investigate and discuss the effect of pericapsular nerve group (PENG) block with liposomal bupivacaine (LB) on postoperative rebound pain following hip fracture in older adults.
Patients and Methods: Ninety patients scheduled for hip fracture surgery were randomized into three groups: LB (liposomal bupivacaine, 30 mL), R (0.375% ropivacaine, 30 mL), and C (saline, 30 mL). MAP and HR were recorded at T1 (pre-induction), T2 (post-intervention), and T3 (skin incision). NRS scores were evaluated at 12– 72 h postoperatively, along with rebound pain, quadriceps function, analgesic consumption, and adverse reactions.
Results: The incidence of rebound pain was significantly lower in the LB and R groups than in the C group (p < 0.05). The AUC of NRS scores over 72 hours was significantly lower in the LB group (2.053 ± 1.258) than in the R (3.600 ± 2.087) and C (4.880 ± 2.739) groups (p < 0.0001). Hemodynamic analysis revealed significant differences in HR between T2 and T3 in all groups (LB: 77.10 ± 11.28 vs 73.77 ± 8.47; R: 79.57 ± 8.05 vs 74.00 ± 8.13; C: 80.50 ± 8.71 vs 84.13 ± 8.07; p < 0.05). MAP in the LB group differed significantly from Group C across the three time points (p < 0.05). There were no significant differences between the groups in adverse events.
Conclusion: LB PENG blockade reduces rebound pain incidence post-nerve block in elderly hip fracture patients, decreases PCA demand, preserves quadriceps function, and enhances satisfaction.
Keywords: rebound pain after nerve block, PENG block, liposomal bupivacaine, hip fracture
1Anesthesiology Department, The Fourth Affiliated Hospital of Anhui Medical University, ChaoHu, Hefei, People’s Republic of China; 2Anesthesiology Department, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoqiong Xia, Anesthesiology Department, The Fourth Affiliated Hospital of Anhui Medical University, ChaoHu, Hefei, Anhui Province, 238000, People’s Republic of China, Tel +8613966386669, Email xxq2366833@sina.com Yuanhai Li, Anesthesiology Department, the First Affiliated Hospital of AnHui Medical University, Hefei, 230000, People’s Republic of China, Tel +8613505697561, Email liyuanhai-1@163.com
Objective: This study aims to investigate and discuss the effect of pericapsular nerve group (PENG) block with liposomal bupivacaine (LB) on postoperative rebound pain following hip fracture in older adults.
Patients and Methods: Ninety patients scheduled for hip fracture surgery were randomized into three groups: LB (liposomal bupivacaine, 30 mL), R (0.375% ropivacaine, 30 mL), and C (saline, 30 mL). MAP and HR were recorded at T1 (pre-induction), T2 (post-intervention), and T3 (skin incision). NRS scores were evaluated at 12– 72 h postoperatively, along with rebound pain, quadriceps function, analgesic consumption, and adverse reactions.
Results: The incidence of rebound pain was significantly lower in the LB and R groups than in the C group (p < 0.05). The AUC of NRS scores over 72 hours was significantly lower in the LB group (2.053 ± 1.258) than in the R (3.600 ± 2.087) and C (4.880 ± 2.739) groups (p < 0.0001). Hemodynamic analysis revealed significant differences in HR between T2 and T3 in all groups (LB: 77.10 ± 11.28 vs 73.77 ± 8.47; R: 79.57 ± 8.05 vs 74.00 ± 8.13; C: 80.50 ± 8.71 vs 84.13 ± 8.07; p < 0.05). MAP in the LB group differed significantly from Group C across the three time points (p < 0.05). There were no significant differences between the groups in adverse events.
Conclusion: LB PENG blockade reduces rebound pain incidence post-nerve block in elderly hip fracture patients, decreases PCA demand, preserves quadriceps function, and enhances satisfaction.
Keywords: rebound pain after nerve block, PENG block, liposomal bupivacaine, hip fracture