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已发表论文
BST2表达、预后意义及免疫相关性的泛癌分析
Authors Zhao YL, Li W, Zhang SM, Chen SB, Ren CC
Received 28 August 2025
Accepted for publication 18 November 2025
Published 5 December 2025 Volume 2025:17 Pages 3059—3072
DOI https://doi.org/10.2147/CMAR.S563888
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Bilikere Dwarakanath
Yun-Long Zhao,1 Wei Li,1 Shi-Ming Zhang,1 Si-Bo Chen,2 Cheng-Cheng Ren3
1Plastic Surgery Laser Center, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China; 2Department of Plastic Surgery, The First Affiliated Hospital of Harbin City, Harbin, Heilongjiang, 150001, People’s Republic of China; 3Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China
Correspondence: Cheng-Cheng Ren, Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China, Tel +86 13946010333, Email rencc82@outlook.com
Objective: This study aimed to investigate the expression of the bone marrow stromal cell antigen 2 (BST2) gene in malignant tumors originating from various tissues and to explore its clinical significance.
Methods: We employed the TCGA database, R software, GeneMANIA database, and biological information analysis technologies to analyze the expression of the BST2 gene across various tumor tissues at different pathological stages and to assess its association with tumor prognosis, mutations, immune invasion, immune checkpoint-related genes, and associated pathways. Validation was performed using skin cutaneous melanoma cell lines, including M14, A375, B16-F10, and A2058.
Results: The expression of the BST2 gene varied across tumors of different origins, showing both increased and decreased levels. BST2 expression was closely associated with patient prognosis. In pan-kidney cohort, renal clear cell carcinoma, pancreatic cancer, and uterine sarcoma, its expression significantly differed across pathological stages. Additionally, in most tumors, BST2 expression correlated positively with immune infiltration and was linked to immune checkpoint-related genes. Validation of skin cutaneous melanoma cell lines displayed BST2 expression was significantly elevated in melanoma cell lines compared with the normal human melanocyte line.
Conclusion: This pan-cancer analysis highlights the correlation between BST2 expression and tumor type, prognosis, pathological stage, tumor mutations, and immune invasion. The findings suggest that BST2 may serve as an effective prognostic biomarker with potential applications in clinical diagnosis and treatment.
Keywords: bioinformation, BST2, database, immune infiltration, pan-cancer
1Plastic Surgery Laser Center, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China; 2Department of Plastic Surgery, The First Affiliated Hospital of Harbin City, Harbin, Heilongjiang, 150001, People’s Republic of China; 3Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People’s Republic of China
Correspondence: Cheng-Cheng Ren, Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China, Tel +86 13946010333, Email rencc82@outlook.com
Objective: This study aimed to investigate the expression of the bone marrow stromal cell antigen 2 (BST2) gene in malignant tumors originating from various tissues and to explore its clinical significance.
Methods: We employed the TCGA database, R software, GeneMANIA database, and biological information analysis technologies to analyze the expression of the BST2 gene across various tumor tissues at different pathological stages and to assess its association with tumor prognosis, mutations, immune invasion, immune checkpoint-related genes, and associated pathways. Validation was performed using skin cutaneous melanoma cell lines, including M14, A375, B16-F10, and A2058.
Results: The expression of the BST2 gene varied across tumors of different origins, showing both increased and decreased levels. BST2 expression was closely associated with patient prognosis. In pan-kidney cohort, renal clear cell carcinoma, pancreatic cancer, and uterine sarcoma, its expression significantly differed across pathological stages. Additionally, in most tumors, BST2 expression correlated positively with immune infiltration and was linked to immune checkpoint-related genes. Validation of skin cutaneous melanoma cell lines displayed BST2 expression was significantly elevated in melanoma cell lines compared with the normal human melanocyte line.
Conclusion: This pan-cancer analysis highlights the correlation between BST2 expression and tumor type, prognosis, pathological stage, tumor mutations, and immune invasion. The findings suggest that BST2 may serve as an effective prognostic biomarker with potential applications in clinical diagnosis and treatment.
Keywords: bioinformation, BST2, database, immune infiltration, pan-cancer