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已发表论文
黑色素瘤综合治疗的新策略：水凝胶的应用、潜力与挑战
Authors Jin Q, Lin SQ, Xue XJ, Wang LL, Jiang MY, Wang J, Wu SF, Hu YY
Received 16 May 2025
Accepted for publication 11 October 2025
Published 18 December 2025 Volume 2025:20 Pages 15313—15342
DOI https://doi.org/10.2147/IJN.S535220
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Professor Jie Huang
Qiang Jin, Shi-Qi Lin, Xiang-Jie Xue, Li-Li Wang, Miao-Yun Jiang, Ji Wang, Su-Fan Wu, Yan-Yan Hu
Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Yan-Yan Hu, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang Province, People’s Republic of China, Email 11818077@zju.edu.cn
Abstract: With the rising incidence and mortality rates of melanoma, the limitations of traditional treatment methods have become increasingly evident. These approaches often lack precision, cause systemic toxicity, or fail to prevent recurrence, falling short of current treatment needs such as efficacy, safety, and long-term tumor control. Melanoma progression involves complex biological features such as uncontrolled proliferation, immune evasion, and metastasis, which are crucial for understanding clinical behavior and guiding treatment design. Hydrogels have recently emerged as a promising platform in the field of cancer therapy due to their tunable physicochemical properties, biocompatibility, and capacity for localized, controlled drug delivery. To provide a comprehensive and methodologically sound overview, we systematically searched the PubMed database using the keywords “hydrogel” and “melanoma” for studies published up to December 2024. Studies were screened based on relevance, originality, and experimental support. This review focuses on hydrogel-based strategies for melanoma treatment, highlighting: (1) recent advances in hydrogel design and functionality; (2) their integration with therapeutic approaches such as immunotherapy, chemotherapy, and photothermal therapy; and (3) their potential in postoperative wound management. In addition, we discuss the role of material selection in hydrogel performance and explore how the combination of distinct therapeutic approaches within hydrogel systems can synergistically improve treatment outcomes. Finally, we address the current challenges facing clinical translation, including safety, efficacy, and regulatory hurdles, while outlining potential pathways to overcome these barriers. This review aims to support future research and clinical innovation by providing a structured, up-to-date overview of hydrogel applications in melanoma therapy.
Plain Language Summary: 1. Advances in hydrogel applications for melanoma treatment are reviewed.
2. Synergistic therapeutic effects of hydrogels for melanoma are summarized.
3. Improvements in hydrogel design for enhanced efficacy and reduced side effects are highlighted.
4. Challenges in clinical translation and scalability of hydrogel-based therapies are discussed.
Keywords: hydrogel, melanoma, drug delivery system, synergistic therapy
Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China
Correspondence: Yan-Yan Hu, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang Province, People’s Republic of China, Email 11818077@zju.edu.cn
Abstract: With the rising incidence and mortality rates of melanoma, the limitations of traditional treatment methods have become increasingly evident. These approaches often lack precision, cause systemic toxicity, or fail to prevent recurrence, falling short of current treatment needs such as efficacy, safety, and long-term tumor control. Melanoma progression involves complex biological features such as uncontrolled proliferation, immune evasion, and metastasis, which are crucial for understanding clinical behavior and guiding treatment design. Hydrogels have recently emerged as a promising platform in the field of cancer therapy due to their tunable physicochemical properties, biocompatibility, and capacity for localized, controlled drug delivery. To provide a comprehensive and methodologically sound overview, we systematically searched the PubMed database using the keywords “hydrogel” and “melanoma” for studies published up to December 2024. Studies were screened based on relevance, originality, and experimental support. This review focuses on hydrogel-based strategies for melanoma treatment, highlighting: (1) recent advances in hydrogel design and functionality; (2) their integration with therapeutic approaches such as immunotherapy, chemotherapy, and photothermal therapy; and (3) their potential in postoperative wound management. In addition, we discuss the role of material selection in hydrogel performance and explore how the combination of distinct therapeutic approaches within hydrogel systems can synergistically improve treatment outcomes. Finally, we address the current challenges facing clinical translation, including safety, efficacy, and regulatory hurdles, while outlining potential pathways to overcome these barriers. This review aims to support future research and clinical innovation by providing a structured, up-to-date overview of hydrogel applications in melanoma therapy.
Plain Language Summary: 1. Advances in hydrogel applications for melanoma treatment are reviewed.
2. Synergistic therapeutic effects of hydrogels for melanoma are summarized.
3. Improvements in hydrogel design for enhanced efficacy and reduced side effects are highlighted.
4. Challenges in clinical translation and scalability of hydrogel-based therapies are discussed.
Keywords: hydrogel, melanoma, drug delivery system, synergistic therapy