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已发表论文
焦虑患者行人工流产术时联合使用羟考酮的丙泊酚最佳剂量用于内脏痛缓解：一项临床试验报告
Authors Chen L , Lu D, Zhang Y, Ji K, Long M, He K , Xie K
Received 29 August 2025
Accepted for publication 28 November 2025
Published 18 December 2025 Volume 2025:19 Pages 11307—11316
DOI https://doi.org/10.2147/DDDT.S563921
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Anastasios Lymperopoulos
Lvlv Chen,1,2 Dajiang Lu,3 Yongguo Zhang,1 Kuiquan Ji,1 Mingbo Long,1 Kai He,1 Kangjie Xie4
1Department of Anesthesiology, The People’s Hospital of Qiannan, Duyun, Guizhou, 558000, People’s Republic of China; 2Qiannan Medical College for Nationalities, Duyun, Guizhou, 558000, People’s Republic of China; 3Department of Gynecology, The People’s Hospital of Qiannan, Duyun, Guizhou, 558000, People’s Republic of China; 4Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 330300, People’s Republic of China
Correspondence: Kangjie Xie, Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 330300, People’s Republic of China, Tel +86-13516721870, Email xiekj9261@126.com
Introduction/Objective: Patients undergoing induced abortion frequently experience acute visceral pain and preoperative anxiety, the latter of which is known to increase anesthetic requirements. This study aimed to determine the median effective dose (ED50) and the 95% effective dose (ED95) of propofol in combination with oxycodone for alleviating visceral pain, specifically testing the finding that anxiety increases the needed propofol dose.
Methods: Female patients, who were scheduled for elective abortion surgeries, with PAS-7 ≥ 8 were classified as anxious group (Group A), while those with PAS-7 < 8 were classified as non-anxious group (Group N). Both groups received an intravenous dose of 0.10 mg/kg of oxycodone prior to surgery.And 2 to 3 minutes later, the first patient in the sequence received an initial dose of 3.50 mg/kg of propofol, with subsequent doses determined by Dixon’s up-and-down method.
Results: The ED50 (95% CI) for propofol was 1.96 mg/kg (1.87– 2.05) in Group N and 2.42 mg/kg (2.30– 2.53) in Group A; the ED95 (95% CI) was 2.10 mg/kg (2.03– 2.39) and 2.60 mg/kg (2.50– 2.95), respectively. The lack of overlap in the 95% confidence intervals indicates a statistically significant difference between groups.
Conclusion: The combination of 0.10 mg/kg oxycodone and propofol was effective for visceral pain suppression during artificial abortion. Notably, patients with anxiety required higher doses of propofol to achieve satisfactory pain relief during abortion surgeries.
Trial Registration: This human study was approved by the Medical Ethics Committee of the People’s Hospital of Qiannan (QNZY-QNYZKYRC-23-0801) and registered at https://www.chictr.org.cn/ (Date: 09/26/2023, ChiCTR2300076169).
Keywords: oxycodone, propofol, preoperative anxiety, visceral pain, abortion, effective dose
1Department of Anesthesiology, The People’s Hospital of Qiannan, Duyun, Guizhou, 558000, People’s Republic of China; 2Qiannan Medical College for Nationalities, Duyun, Guizhou, 558000, People’s Republic of China; 3Department of Gynecology, The People’s Hospital of Qiannan, Duyun, Guizhou, 558000, People’s Republic of China; 4Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 330300, People’s Republic of China
Correspondence: Kangjie Xie, Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 330300, People’s Republic of China, Tel +86-13516721870, Email xiekj9261@126.com
Introduction/Objective: Patients undergoing induced abortion frequently experience acute visceral pain and preoperative anxiety, the latter of which is known to increase anesthetic requirements. This study aimed to determine the median effective dose (ED50) and the 95% effective dose (ED95) of propofol in combination with oxycodone for alleviating visceral pain, specifically testing the finding that anxiety increases the needed propofol dose.
Methods: Female patients, who were scheduled for elective abortion surgeries, with PAS-7 ≥ 8 were classified as anxious group (Group A), while those with PAS-7 < 8 were classified as non-anxious group (Group N). Both groups received an intravenous dose of 0.10 mg/kg of oxycodone prior to surgery.And 2 to 3 minutes later, the first patient in the sequence received an initial dose of 3.50 mg/kg of propofol, with subsequent doses determined by Dixon’s up-and-down method.
Results: The ED50 (95% CI) for propofol was 1.96 mg/kg (1.87– 2.05) in Group N and 2.42 mg/kg (2.30– 2.53) in Group A; the ED95 (95% CI) was 2.10 mg/kg (2.03– 2.39) and 2.60 mg/kg (2.50– 2.95), respectively. The lack of overlap in the 95% confidence intervals indicates a statistically significant difference between groups.
Conclusion: The combination of 0.10 mg/kg oxycodone and propofol was effective for visceral pain suppression during artificial abortion. Notably, patients with anxiety required higher doses of propofol to achieve satisfactory pain relief during abortion surgeries.
Trial Registration: This human study was approved by the Medical Ethics Committee of the People’s Hospital of Qiannan (QNZY-QNYZKYRC-23-0801) and registered at https://www.chictr.org.cn/ (Date: 09/26/2023, ChiCTR2300076169).
Keywords: oxycodone, propofol, preoperative anxiety, visceral pain, abortion, effective dose