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已发表论文
自组装纳米粒子：克服传统纳米药物局限性以增强肿瘤治疗效果
Authors Tang X, Xie R, Zeng B, Yi C, Su H, Chen C, Zhou L, Xia X , Zeng J, Yang J
Received 19 September 2025
Accepted for publication 28 November 2025
Published 18 December 2025 Volume 2025:20 Pages 15185—15211
DOI https://doi.org/10.2147/IJN.S568952
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Eng San Thian
Xinlei Tang,1 Rujia Xie,1 Bozhi Zeng,1 Chengcheng Yi,1 Hui Su,1 Congcong Chen,1 Lili Zhou,1 Xinhua Xia,1 Jianguo Zeng,2 Jing Yang1
1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128, People’s Republic of China
Correspondence: Jianguo Zeng; Jing Yang, Email zengjianguo@hunau.edu.cn; yangjing@hnucm.edu.cn
Abstract: The high mortality rate associated with cancer presents a significant clinical challenge, necessitating breakthroughs to overcome the limitations of traditional therapies, which often entail substantial side effects, as well as the complexities associated with existing nanodelivery systems (NDDS) that lack adequate targeting capabilities. Self-assembled nanoparticles (SANs) form spontaneously through weak interactions between drugs and functional molecules, such as hydrogen bonds and hydrophobic interactions. They exhibit revolutionary advantages, including ultra-high drug loading capacity, stimulus responsiveness, precise drug release, self-driven targeting capabilities, and a straightforward preparation process that does not require complex carrier synthesis. This review systematically summarizes the latest advancements in SANs for tumor therapy, emphasizing their molecular design principles and mainstream preparation strategies, while detailing their efficacy in multi-modal synergistic therapies, including chemotherapy, photodynamic/photothermal therapy, immunotherapy, and gene therapy. The technology of SANs establishes a robust foundation for the development of highly efficient and low-toxicity anti-cancer strategies, demonstrating significant potential to offer a transformative new paradigm for clinical precision therapy. We believe that the continued evolution of SANs holds great promise for clinical translation, potentially offering transformative solutions for personalized oncology in the near future.
keywords: self-assembled nanoparticles, tumor therapy, molecular design, non-covalent interactions, nanodrug delivery system
1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128, People’s Republic of China
Correspondence: Jianguo Zeng; Jing Yang, Email zengjianguo@hunau.edu.cn; yangjing@hnucm.edu.cn
Abstract: The high mortality rate associated with cancer presents a significant clinical challenge, necessitating breakthroughs to overcome the limitations of traditional therapies, which often entail substantial side effects, as well as the complexities associated with existing nanodelivery systems (NDDS) that lack adequate targeting capabilities. Self-assembled nanoparticles (SANs) form spontaneously through weak interactions between drugs and functional molecules, such as hydrogen bonds and hydrophobic interactions. They exhibit revolutionary advantages, including ultra-high drug loading capacity, stimulus responsiveness, precise drug release, self-driven targeting capabilities, and a straightforward preparation process that does not require complex carrier synthesis. This review systematically summarizes the latest advancements in SANs for tumor therapy, emphasizing their molecular design principles and mainstream preparation strategies, while detailing their efficacy in multi-modal synergistic therapies, including chemotherapy, photodynamic/photothermal therapy, immunotherapy, and gene therapy. The technology of SANs establishes a robust foundation for the development of highly efficient and low-toxicity anti-cancer strategies, demonstrating significant potential to offer a transformative new paradigm for clinical precision therapy. We believe that the continued evolution of SANs holds great promise for clinical translation, potentially offering transformative solutions for personalized oncology in the near future.
keywords: self-assembled nanoparticles, tumor therapy, molecular design, non-covalent interactions, nanodrug delivery system