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已发表论文
心理应激源激素和细胞因子对白癜风患者免疫细胞谱的影响：动物模型外周血模拟的改进方向
Authors Tang N, Zhang QW, Xiong XF, Liu XW, Wang GE, Wu YH
Received 24 July 2025
Accepted for publication 2 December 2025
Published 17 December 2025 Volume 2025:18 Pages 3457—3469
DOI https://doi.org/10.2147/CCID.S555801
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Rungsima Wanitphakdeedecha
Nan Tang,1,* Qi-Wen Zhang,2,* Xi-Feng Xiong,3 Xing-Wei Liu,4 Guo-En Wang,2 Yan-Hua Wu1
1Departments of Traditional Chinese Medicine, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, 510220, People’s Republic of China; 2School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, 510220, People’s Republic of China; 4The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan-Hua Wu, Departments of Traditional Chinese Medicine, Guangzhou Red Cross Hospital, Jinan University, No. 396 Tongfu Zhong Road, Guangzhou, Guangdong Province, People’s Republic of China, Email wuyanhua368@163.com Guo-En Wang, Email wangge07@126.com
Abstract: Vitiligo is an autoimmune disease with a localized or generalized depigmentation in the skin, and characterized by psychological stress induced by unattractive appearance. Psychological stress induces alterations in immune cell populations through hormones and cytokines, however, the pathogenesis of psychological stress on vitiligo remains unclear. This review discussed the effects of psychological stress-derived hormones and cytokines including macrophage migration inhibitory factor, progesterone, glucocorticoids, estrogens, and norepinephrine on immunocytes including regulatory T cells, natural killer cells, dendritic cells, B cells, monocytes, and neutrophils. In addition, the review also explored the relationship between melanocytes and immune cells, as well as the conditions of several major animal models simulating the peripheral blood in human vitiligo. This review intended to provide better insights into the complex pathogenesis of vitiligo related to psychological stress, and developing new targets for the prevention and treatments of vitiligo.
Keywords: vitiligo, psychological stress, immunocyte profiles, hormones
1Departments of Traditional Chinese Medicine, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong, 510220, People’s Republic of China; 2School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, 510220, People’s Republic of China; 4The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yan-Hua Wu, Departments of Traditional Chinese Medicine, Guangzhou Red Cross Hospital, Jinan University, No. 396 Tongfu Zhong Road, Guangzhou, Guangdong Province, People’s Republic of China, Email wuyanhua368@163.com Guo-En Wang, Email wangge07@126.com
Abstract: Vitiligo is an autoimmune disease with a localized or generalized depigmentation in the skin, and characterized by psychological stress induced by unattractive appearance. Psychological stress induces alterations in immune cell populations through hormones and cytokines, however, the pathogenesis of psychological stress on vitiligo remains unclear. This review discussed the effects of psychological stress-derived hormones and cytokines including macrophage migration inhibitory factor, progesterone, glucocorticoids, estrogens, and norepinephrine on immunocytes including regulatory T cells, natural killer cells, dendritic cells, B cells, monocytes, and neutrophils. In addition, the review also explored the relationship between melanocytes and immune cells, as well as the conditions of several major animal models simulating the peripheral blood in human vitiligo. This review intended to provide better insights into the complex pathogenesis of vitiligo related to psychological stress, and developing new targets for the prevention and treatments of vitiligo.
Keywords: vitiligo, psychological stress, immunocyte profiles, hormones