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已发表论文
揭开沉默之谜：探究耳鸣的病理生理学及中医的希望
Authors Xing Q, Jiang Y, Xu D, Hou Z, Xu J
Received 19 June 2025
Accepted for publication 28 August 2025
Published 16 December 2025 Volume 2025:18 Pages 7559—7577
DOI https://doi.org/10.2147/IJGM.S546037
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Qingchang Xing, Yueying Jiang, Dongye Xu, Zhiming Hou, Jichao Xu
Department of Traditional Chinese Medicine, The Eighth Medical Center of PLA General Hospital, Beijing, People’s Republic of China
Correspondence: Jichao Xu, Department of Traditional Chinese Medicine, The Eighth Medical Center of PLA General Hospital, 17 Heishan Hujia, Haidian District, Beijing, People’s Republic of China, Email 17710240585@163.com
Abstract: Tinnitus is a prevalent condition often associated with hearing loss. Tinnitus may persist throughout an individual’s life and can result in a range of negative outcomes, including annoyance, anxiety, depression, insomnia, heightened auditory sensitivity, difficulties with concentration, and, in severe cases, suicidal ideation. Although not all individuals experiencing tinnitus require medical intervention, approximately 20% of them pursue clinical assistance. In addition to lidocaine, no pharmacological agents have demonstrated sustained efficacy in the management of tinnitus. Traditional Chinese Medicine (TCM) has shown promise for alleviating tinnitus. Consequently, this review aimed to synthesize the latest findings from both animal and clinical studies, while also examining the potential for comprehensive treatment approaches for tinnitus using TCM based on the understanding of its pathophysiology and neuroimaging mechanisms.
Keywords: tinnitus, hearing loss, auditory system, antidepressants, TCM
Department of Traditional Chinese Medicine, The Eighth Medical Center of PLA General Hospital, Beijing, People’s Republic of China
Correspondence: Jichao Xu, Department of Traditional Chinese Medicine, The Eighth Medical Center of PLA General Hospital, 17 Heishan Hujia, Haidian District, Beijing, People’s Republic of China, Email 17710240585@163.com
Abstract: Tinnitus is a prevalent condition often associated with hearing loss. Tinnitus may persist throughout an individual’s life and can result in a range of negative outcomes, including annoyance, anxiety, depression, insomnia, heightened auditory sensitivity, difficulties with concentration, and, in severe cases, suicidal ideation. Although not all individuals experiencing tinnitus require medical intervention, approximately 20% of them pursue clinical assistance. In addition to lidocaine, no pharmacological agents have demonstrated sustained efficacy in the management of tinnitus. Traditional Chinese Medicine (TCM) has shown promise for alleviating tinnitus. Consequently, this review aimed to synthesize the latest findings from both animal and clinical studies, while also examining the potential for comprehensive treatment approaches for tinnitus using TCM based on the understanding of its pathophysiology and neuroimaging mechanisms.
Keywords: tinnitus, hearing loss, auditory system, antidepressants, TCM