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已发表论文
CD209 基因突变患者感染阿罗西分枝杆菌：一例罕见病例报告
Authors Su J, Ni K, Du Y, Yu W, Xu K, Sheng J
Received 7 October 2025
Accepted for publication 8 December 2025
Published 16 December 2025 Volume 2025:18 Pages 6715—6717
DOI https://doi.org/10.2147/IDR.S572632
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Junwei Su,1,* Kou Ni,2,* Yueting Du,3 Wei Yu,1 Kaijin Xu,1 Jifang Sheng1
1The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Medical Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 3Department of Gastroenterology and Infectious Diseases, Dongyang Hospital of Traditional Chinese Medicine, Jinhua, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Kaijin Xu, The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email zdyxyxkj@zju.edu.cn Jifang Sheng, The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email jifang_sheng@zju.edu.cn
Abstract: We report a case of an adult male with a history of recurrent cough and chest pain for five years. Mycobacterium arosiense was identified in his alveolar lavage fluid, and whole-exome sequencing revealed heterozygosity for CD209 in this patient. After 17 months of combined antibiotic therapy, the patient recovered completely.
Keywords: Mycobacterium arosiense, CD209 mutation, pneumonia
1The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2Department of Medical Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 3Department of Gastroenterology and Infectious Diseases, Dongyang Hospital of Traditional Chinese Medicine, Jinhua, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Kaijin Xu, The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email zdyxyxkj@zju.edu.cn Jifang Sheng, The Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email jifang_sheng@zju.edu.cn
Abstract: We report a case of an adult male with a history of recurrent cough and chest pain for five years. Mycobacterium arosiense was identified in his alveolar lavage fluid, and whole-exome sequencing revealed heterozygosity for CD209 in this patient. After 17 months of combined antibiotic therapy, the patient recovered completely.
Keywords: Mycobacterium arosiense, CD209 mutation, pneumonia