111536
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
慢性心力衰竭患者血清中 TNFAIP3 和 NLRP3 水平作为主要不良心血管事件新型生物标志物的队列研究
Authors Mo D , Yang L, Zhang P, Zhang M, Guan J, Wang G, Dai H
Received 19 September 2025
Accepted for publication 25 November 2025
Published 16 December 2025 Volume 2025:18 Pages 17509—17521
DOI https://doi.org/10.2147/JIR.S567963
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Chengming Fan
Degang Mo,1,2 Lijia Yang,2 Peng Zhang,1,2 Miao Zhang,2 Jun Guan,2 Guoan Wang,2 Hongyan Dai2
1School of Medicine, Qingdao University, Qingdao, 266000, People’s Republic of China; 2Department of Cardiology, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China
Correspondence: Guoan Wang, Department of Cardiology, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China, Email guoanwang1@163.com Hongyan Dai, Department of Cardiology, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China, Email DrDaihy@163.com
Purpose: Chronic heart failure (CHF) is a major public health issue with high morbidity and mortality, where inflammation plays a key role in its progression. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) and NOD-like receptor protein 3 (NLRP3) regulate inflammatory responses, but their prognostic value in CHF remains unclear. This study aims to investigate the association between serum levels of TNFAIP3 and NLRP3 and the risk of major adverse cardiovascular events (MACEs) in patients with CHF.
Patients and Methods: A cohort study was conducted involving 318 patients with CHF and 122 controls. Serum levels of TNFAIP3 and NLRP3 were measured using enzyme-linked immunosorbent assay method. Propensity score matching (PSM) was used to control for confounders. Multivariable logistic regression, restricted cubic spline, threshold effect, and receiver operating characteristic (ROC) analyses were employed to evaluate the associations between biomarker levels and MACEs over a 6-month follow-up.
Results: After PSM, patients with CHF had significantly higher TNFAIP3 and NLRP3 levels than controls (both p < 0.001). Compared to CHF patients without MACEs, those with MACEs exhibited significantly lower levels of TNFAIP3 and higher levels of NLRP3. Multivariable analysis confirmed TNFAIP3 as an independent protective factor [odds ratio (OR)= 0.61, 95% confidence interval (CI): 0.40– 0.93) and NLRP3 as an independent risk factor (OR = 1.24, 95% CI: 1.17– 1.31) for MACEs. ROC analysis demonstrated NLRP3 (AUROC = 0.756) had better predictive ability than TNFAIP3 (AUROC = 0.611).
Conclusion: TNFAIP3 and NLRP3 are significantly associated with the risk of MACEs in patients with CHF and NLRP3 demonstrates stronger predictive performance than TNFAIP3.
Keywords: tumor necrosis factor alpha-induced protein 3, NOD-like receptor protein 3, major adverse cardiovascular events, chronic heart failure, risk stratification
1School of Medicine, Qingdao University, Qingdao, 266000, People’s Republic of China; 2Department of Cardiology, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China
Correspondence: Guoan Wang, Department of Cardiology, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China, Email guoanwang1@163.com Hongyan Dai, Department of Cardiology, Qingdao Municipal Hospital, Qingdao, 266011, People’s Republic of China, Email DrDaihy@163.com
Purpose: Chronic heart failure (CHF) is a major public health issue with high morbidity and mortality, where inflammation plays a key role in its progression. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) and NOD-like receptor protein 3 (NLRP3) regulate inflammatory responses, but their prognostic value in CHF remains unclear. This study aims to investigate the association between serum levels of TNFAIP3 and NLRP3 and the risk of major adverse cardiovascular events (MACEs) in patients with CHF.
Patients and Methods: A cohort study was conducted involving 318 patients with CHF and 122 controls. Serum levels of TNFAIP3 and NLRP3 were measured using enzyme-linked immunosorbent assay method. Propensity score matching (PSM) was used to control for confounders. Multivariable logistic regression, restricted cubic spline, threshold effect, and receiver operating characteristic (ROC) analyses were employed to evaluate the associations between biomarker levels and MACEs over a 6-month follow-up.
Results: After PSM, patients with CHF had significantly higher TNFAIP3 and NLRP3 levels than controls (both p < 0.001). Compared to CHF patients without MACEs, those with MACEs exhibited significantly lower levels of TNFAIP3 and higher levels of NLRP3. Multivariable analysis confirmed TNFAIP3 as an independent protective factor [odds ratio (OR)= 0.61, 95% confidence interval (CI): 0.40– 0.93) and NLRP3 as an independent risk factor (OR = 1.24, 95% CI: 1.17– 1.31) for MACEs. ROC analysis demonstrated NLRP3 (AUROC = 0.756) had better predictive ability than TNFAIP3 (AUROC = 0.611).
Conclusion: TNFAIP3 and NLRP3 are significantly associated with the risk of MACEs in patients with CHF and NLRP3 demonstrates stronger predictive performance than TNFAIP3.
Keywords: tumor necrosis factor alpha-induced protein 3, NOD-like receptor protein 3, major adverse cardiovascular events, chronic heart failure, risk stratification