111536
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
推进纳米医学：用于骨缺损修复与再生
Authors Niu Z, Fan Y, Yin L, Tong Y, Yao L, Ding S, Chen J, Bi Q, Xia C
Received 7 June 2025
Accepted for publication 2 December 2025
Published 16 December 2025 Volume 2025:20 Pages 15043—15062
DOI https://doi.org/10.2147/IJN.S545353
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Farooq A. Shiekh
Zexuan Niu,1– 4,* Yong Fan,1– 4,* Li Yin,1– 4 Yu Tong,1,3,4 Longtao Yao,1– 4 Sheyuan Ding,1,3,4 Jiaxin Chen,5 Qing Bi,1– 4 Chen Xia1,3,4
1Department of Sports Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China; 3Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People’s Republic of China; 4Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People’s Republic of China; 5Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Chen Xia, Email 49707783@qq.com Qing Bi, Email bqzjsrmyy@163.com
Abstract: The clinical significance of bone defects is not well understood; these pathological conditions not only compromise patients’ quality of life but may also result in permanent functional impairment if inadequately addressed. Consequently, the development of effective therapeutic interventions for bone defect repair and regeneration is a critical medical challenge. Recent advancements in nanotechnology, particularly engineered nanoparticle systems, have introduced promising new strategies for bone tissue regeneration. However, it is important to note that most nanoparticle-based approaches remain at the preclinical or experimental stage, and their clinical translation is still limited. These sophisticated nanomaterials enhance critical biological processes including osteoconduction, osteoinduction, and osteogenesis which collectively facilitate optimal bone healing. Notably, certain nanoparticles possess intrinsic properties that enable modulation of the inflammatory microenvironment and immunological responses during bone repair. Furthermore, the integration of nanoparticles with complementary biomaterials yielded composite systems with superior therapeutic efficacy in addressing complex bone defects. This comprehensive review summarizes the pathophysiological mechanisms underlying bone repair, systematically examines the preclinical and experimental therapeutic applications of various nanoparticle formulations across different phases of the bone-healing cascade, highlights recent technological innovations in nanoparticle engineering for enhanced bone regeneration, and critically discusses the existing limitations and challenges of clinical translation as well as promising future research directions in this rapidly evolving field.
Keywords: bone regeneration, bone defects, nanoparticles, osteogenesis
1Department of Sports Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000, People’s Republic of China; 3Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People’s Republic of China; 4Institute of Sports Medicine and Osteoarthropathy of Hangzhou Medical College, Hangzhou, Zhejiang, 310000, People’s Republic of China; 5Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Chen Xia, Email 49707783@qq.com Qing Bi, Email bqzjsrmyy@163.com
Abstract: The clinical significance of bone defects is not well understood; these pathological conditions not only compromise patients’ quality of life but may also result in permanent functional impairment if inadequately addressed. Consequently, the development of effective therapeutic interventions for bone defect repair and regeneration is a critical medical challenge. Recent advancements in nanotechnology, particularly engineered nanoparticle systems, have introduced promising new strategies for bone tissue regeneration. However, it is important to note that most nanoparticle-based approaches remain at the preclinical or experimental stage, and their clinical translation is still limited. These sophisticated nanomaterials enhance critical biological processes including osteoconduction, osteoinduction, and osteogenesis which collectively facilitate optimal bone healing. Notably, certain nanoparticles possess intrinsic properties that enable modulation of the inflammatory microenvironment and immunological responses during bone repair. Furthermore, the integration of nanoparticles with complementary biomaterials yielded composite systems with superior therapeutic efficacy in addressing complex bone defects. This comprehensive review summarizes the pathophysiological mechanisms underlying bone repair, systematically examines the preclinical and experimental therapeutic applications of various nanoparticle formulations across different phases of the bone-healing cascade, highlights recent technological innovations in nanoparticle engineering for enhanced bone regeneration, and critically discusses the existing limitations and challenges of clinical translation as well as promising future research directions in this rapidly evolving field.
Keywords: bone regeneration, bone defects, nanoparticles, osteogenesis