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已发表论文
PI3K p85α 和 p53 蛋白在结直肠癌组织中的表达及意义
Authors Wu X , Wang J, Li S, Yang Y
Received 19 September 2025
Accepted for publication 9 December 2025
Published 15 December 2025 Volume 2025:17 Pages 3129—3138
DOI https://doi.org/10.2147/CMAR.S565385
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Bilikere Dwarakanath
Xuefang Wu,1 Jing Wang,1 Shuang Li,2 Yingchun Yang2
1Department of Pathology, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315100, People’s Republic of China; 2Department of Pathology, Guizhou Provincial People’s Hospital, Guiyang, 550002, People’s Republic of China
Correspondence: Xuefang Wu, Department of Pathology, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315100, People’s Republic of China, Email xuefangwupat@163.com
Aim: To evaluate the expression of PI3K p85α and p53 proteins in colorectal cancer (CRC) tissues, investigate their roles in carcinogenesis and progression, and analyze their associations with clinicopathological characteristics and patient prognosis.
Methods: Immunohistochemistry was used to assess the expression of PI3K p85α and p53 proteins in CRC tissues and matched paracancerous mucosa from 267 patients. The associations between protein expression and clinicopathological characteristics were analyzed. Follow-up data were evaluated using univariate Kaplan–Meier survival analysis and multivariate Cox regression analysis.
Results: The positive rate of PI3K p85α was significantly higher in CRC tissues than in paracancerous mucosa (80.2% vs 17.6%, P< 0.001) and was associated with clinical stage (χ2=5.261, P=0.022). p53 expression profiles were markedly different between CRC and normal tissues, with a significantly higher rate of p53 overexpression in CRC (62.9% vs 0%, P< 0.001). Importantly, both negative and high p53 expression were associated with a higher incidence of lymph node metastasis (P< 0.05). In survival analysis, clinical stage, tumor differentiation, and PI3K p85α expression were identified as independent prognostic factors for CRC patients (P< 0.05).
Conclusion: PI3K p85α and p53 are implicated in CRC development and progression. The detection of these proteins offers clinical value for early diagnosis and predicting tumor behavior, while PI3K p85α expression may serve as a valuable biomarker for prognostic assessment in CRC.
Keywords: colorectal carcinoma, PI3K p85α, p53, immunohistochemistry
1Department of Pathology, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315100, People’s Republic of China; 2Department of Pathology, Guizhou Provincial People’s Hospital, Guiyang, 550002, People’s Republic of China
Correspondence: Xuefang Wu, Department of Pathology, The Affiliated People’s Hospital of Ningbo University, Ningbo, 315100, People’s Republic of China, Email xuefangwupat@163.com
Aim: To evaluate the expression of PI3K p85α and p53 proteins in colorectal cancer (CRC) tissues, investigate their roles in carcinogenesis and progression, and analyze their associations with clinicopathological characteristics and patient prognosis.
Methods: Immunohistochemistry was used to assess the expression of PI3K p85α and p53 proteins in CRC tissues and matched paracancerous mucosa from 267 patients. The associations between protein expression and clinicopathological characteristics were analyzed. Follow-up data were evaluated using univariate Kaplan–Meier survival analysis and multivariate Cox regression analysis.
Results: The positive rate of PI3K p85α was significantly higher in CRC tissues than in paracancerous mucosa (80.2% vs 17.6%, P< 0.001) and was associated with clinical stage (χ2=5.261, P=0.022). p53 expression profiles were markedly different between CRC and normal tissues, with a significantly higher rate of p53 overexpression in CRC (62.9% vs 0%, P< 0.001). Importantly, both negative and high p53 expression were associated with a higher incidence of lymph node metastasis (P< 0.05). In survival analysis, clinical stage, tumor differentiation, and PI3K p85α expression were identified as independent prognostic factors for CRC patients (P< 0.05).
Conclusion: PI3K p85α and p53 are implicated in CRC development and progression. The detection of these proteins offers clinical value for early diagnosis and predicting tumor behavior, while PI3K p85α expression may serve as a valuable biomarker for prognostic assessment in CRC.
Keywords: colorectal carcinoma, PI3K p85α, p53, immunohistochemistry