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已发表论文
以键合为中心的透明质酸改性：合成、加工及生物医学应用
Authors Yang A, Yang P, Shen N, Wu R, Liu X, Ju Y, Lei L , Fang B
Received 15 August 2025
Accepted for publication 29 November 2025
Published 15 December 2025 Volume 2025:20 Pages 15063—15108
DOI https://doi.org/10.2147/IJN.S560798
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Lijie Grace Zhang
Anqi Yang,1 Pu Yang,1 Naisi Shen,1 Rui Wu,1 Xiangjun Liu,1 Yikun Ju,1 Lanjie Lei,2 Bairong Fang1
1Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 2Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, People’s Republic of China
Correspondence: Lanjie Lei, Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, People’s Republic of China, Email leilanjie1988@163.com Bairong Fang, Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China, Email fbrfbr2004@csu.edu.cn
Abstract: Hyaluronic acid (HA), a natural polysaccharide present in human connective tissues, is widely used in biomedicine because of its excellent biocompatibility and biodegradability. However, products based on natural HA have several drawbacks, leading to widespread studies on the modification and processing of HA to improve its clinical use. This review discusses common methods of modifying HA, including physical and chemical modification as well as crosslinking. It focuses in detail on various chemical modification strategies from the perspective of the resultant chemical bonds, systematically organizes HA chemistry according to bond types, and refines the design rules for linking chemistry in relation to degradability, mechanical properties, responsiveness, and safety. It then summarizes the latest applications of HA-based products in the fields of ophthalmology, bone and joint treatment, aesthetic medicine, wound healing, and drug delivery. Finally, it explores challenges for the clinical application of HA and provides an outlook on future research directions. By summarizing the applications of HA across distinct biomedical domains, we hope to provide new ideas and directions for its further development and use.
Keywords: hyaluronic acid, modification, clinical application, biocompatibility, drug delivery
1Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China; 2Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, People’s Republic of China
Correspondence: Lanjie Lei, Key Laboratory of Artificial Organs and Computational Medicine of Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, 310015, People’s Republic of China, Email leilanjie1988@163.com Bairong Fang, Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China, Email fbrfbr2004@csu.edu.cn
Abstract: Hyaluronic acid (HA), a natural polysaccharide present in human connective tissues, is widely used in biomedicine because of its excellent biocompatibility and biodegradability. However, products based on natural HA have several drawbacks, leading to widespread studies on the modification and processing of HA to improve its clinical use. This review discusses common methods of modifying HA, including physical and chemical modification as well as crosslinking. It focuses in detail on various chemical modification strategies from the perspective of the resultant chemical bonds, systematically organizes HA chemistry according to bond types, and refines the design rules for linking chemistry in relation to degradability, mechanical properties, responsiveness, and safety. It then summarizes the latest applications of HA-based products in the fields of ophthalmology, bone and joint treatment, aesthetic medicine, wound healing, and drug delivery. Finally, it explores challenges for the clinical application of HA and provides an outlook on future research directions. By summarizing the applications of HA across distinct biomedical domains, we hope to provide new ideas and directions for its further development and use.
Keywords: hyaluronic acid, modification, clinical application, biocompatibility, drug delivery