Mingyang Wu,1,2,* Fang Li,1,2,* Geyang Xu,3,* Xingyu Chen,1,2 Yu Zhang,1 Xu Yao1 

1Department of Allergy and Rheumatology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People’s Republic of China; 2Jiangsu Provincial Key Laboratory of Dermatololgy, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People’s Republic of China; 3Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA

*These authors contributed equally to this work

Correspondence: Xu Yao; Yu Zhang, Department of Allergy and Rheumatology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 12 Jiangwangmiao Street, Xuanwu District, Nanjing, Jiangsu Province, People’s Republic of China, Email dryao_xu@126.com; 13584012907@163.com
摘要：

背景：随着全球人口老龄化，老年特应性皮炎(AD)作为AD的一种特殊亚型，逐渐被关注。本研究旨在探讨中国队列中老年AD患者的临床及血液学表型特征。

方法：将593例符合《中国特应性皮炎诊断标准》（CCAD）的患者按年龄分为3组：2-17岁(儿童组)、18-59岁(成人组)、≥60岁(老年组)。通过标准化问卷与体格检查评估患者的临床特征及相关因素，同时收集部分患者血清总IgE与全血细胞计数，并匹配相应老年健康对照。

结果：约3/4的老年AD患者为晚发型(首次发病≥60岁)，且男性占比更高(男女比2.03:1)；皮损呈广泛分布模式，超80%的老年AD患者为中重度(SCORAD评分≥25)AD，与年轻组相比，其瘙痒程度更重、生活质量受损更明显、治疗效果更差。内源性亚型占比随年龄增长而升高，在老年AD中占47%。与其他年龄组相比，老年AD患者的单核细胞计数及比例更高，但淋巴细胞计数更低；老年AD患者的湿疹面积及严重程度指数(EASI)与嗜酸性粒细胞计数呈正相关，与淋巴细胞计数及比例呈负相关。