115563
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
泛凋亡作为药物性肝损伤的潜在治疗靶点：一篇叙述性综述
Authors Zhang X, Zhou Z , Xie Z , Chen J, Deng Y , Fang Y, Deng J, Ye X
Received 29 September 2025
Accepted for publication 23 December 2025
Published 8 January 2026 Volume 2026:19 569771
DOI https://doi.org/10.2147/JIR.S569771
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Fatih Türker
Xinru Zhang,1 Zhipin Zhou,1 Zhuohua Xie,2 Jieyi Chen,1 Yanting Deng,2 Yibin Fang,1 Jiasheng Deng,2 Xiaoxue Ye1
1Liuzhou People’s Hospital Affiliated to Guangxi Medical University, Guangxi, 545006, People’s Republic of China; 2School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, People’s Republic of China
Correspondence: Zhipin Zhou, Liuzhou People’s Hospital Affiliated to Guangxi Medical University, 8 Wenchang Road, Cheng Zhong District, Liuzhou, Guangxi, People’s Republic of China, Tel +86− 18776921947, Email gxzhouzhipin@126.com
摘要 泛凋亡（PANoptosis）是一种近年来提出的新型程序性细胞死亡方式，其特征是由多蛋白复合物泛凋亡小体（PANoptosome）共同调控细胞焦亡、凋亡和坏死性凋亡三种经典死亡途径，且无法被其中任何一种途径单独解释。泛凋亡的启动依赖于泛凋亡小体的组装与激活，该过程已被证实与炎症性疾病、神经退行性疾病、癌症及肺部疾病等多种疾病的发生发展密切相关。然而，泛凋亡在药物性肝损伤（DILI）中的作用尚未得到全面的讨论。DILI是临床常见的药物不良反应，其发生与肝细胞死亡密切相关。因此，本文旨在综述泛凋亡的分子机制及其泛凋亡小体的组装过程，探讨细胞凋亡、坏死性凋亡和焦亡之间的相互作用，并深入分析泛凋亡在DILI中的潜在作用。深入探索天然产物通过抑制泛凋亡小体的组装，或靶向ZBP1、AIM2、NLRP3等关键节点以干预泛凋亡，有可能为治疗DILI提供巨大机遇。
1Liuzhou People’s Hospital Affiliated to Guangxi Medical University, Guangxi, 545006, People’s Republic of China; 2School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, People’s Republic of China
Correspondence: Zhipin Zhou, Liuzhou People’s Hospital Affiliated to Guangxi Medical University, 8 Wenchang Road, Cheng Zhong District, Liuzhou, Guangxi, People’s Republic of China, Tel +86− 18776921947, Email gxzhouzhipin@126.com
摘要 泛凋亡（PANoptosis）是一种近年来提出的新型程序性细胞死亡方式，其特征是由多蛋白复合物泛凋亡小体（PANoptosome）共同调控细胞焦亡、凋亡和坏死性凋亡三种经典死亡途径，且无法被其中任何一种途径单独解释。泛凋亡的启动依赖于泛凋亡小体的组装与激活，该过程已被证实与炎症性疾病、神经退行性疾病、癌症及肺部疾病等多种疾病的发生发展密切相关。然而，泛凋亡在药物性肝损伤（DILI）中的作用尚未得到全面的讨论。DILI是临床常见的药物不良反应，其发生与肝细胞死亡密切相关。因此，本文旨在综述泛凋亡的分子机制及其泛凋亡小体的组装过程，探讨细胞凋亡、坏死性凋亡和焦亡之间的相互作用，并深入分析泛凋亡在DILI中的潜在作用。深入探索天然产物通过抑制泛凋亡小体的组装，或靶向ZBP1、AIM2、NLRP3等关键节点以干预泛凋亡，有可能为治疗DILI提供巨大机遇。