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已发表论文
一例免疫功能正常的患者因黄曲霉菌所致的原发性皮肤曲霉病
Authors Wang Z, Yang R, Xiao Y, Huang B, Yang Z, Yang L
Received 6 September 2025
Accepted for publication 30 December 2025
Published 9 January 2026 Volume 2026:19 565781
DOI https://doi.org/10.2147/IDR.S565781
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sara Mina
Zhengfang Wang,1,* Rong Yang,2,* Yonghong Xiao,1 Bo Huang,1 Zhi Yang,1 Luhui Yang1
1Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Wound and Ostomy Clinic, Outpatient Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhi Yang, Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming, Yunnan Province, 650032, People’s Republic of China, Email vipyz@126.com Luhui Yang, Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming, Yunnan Province, 650032, People’s Republic of China, Email lhyang2020@126.com
Abstract: Invasive aspergillosis is a life-threatening infection caused by Aspergillus species, affecting the lungs, central nervous system, nasal and orbital regions, and skin. Primary cutaneous aspergillosis (PCA) occurs through direct skin inoculation via trauma, burns, or surgical wounds, with Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger as common causative species, and is rare in immunocompetent individuals. We report a case of PCA in a 56-year-old immunocompetent patient with facial and right ankle ulcers, persisting for two years. The patient had no history of diabetes, corticosteroid use, or immunodeficiency. Fungal culture and metagenomic next-generation sequencing (mNGS) confirmed A. flavus infection. Voriconazole therapy, surgical debridement, and specialized wound care led to the gradual healing of the ulcers. This case highlights the importance of early diagnosis and intervention to prevent infection spread and progression to systemic aspergillosis or septic shock.
Keywords: invasive aspergillosis, primary cutaneous aspergillosis, A. flavus, fungal infection
1Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Wound and Ostomy Clinic, Outpatient Department, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhi Yang, Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming, Yunnan Province, 650032, People’s Republic of China, Email vipyz@126.com Luhui Yang, Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming, Yunnan Province, 650032, People’s Republic of China, Email lhyang2020@126.com
Abstract: Invasive aspergillosis is a life-threatening infection caused by Aspergillus species, affecting the lungs, central nervous system, nasal and orbital regions, and skin. Primary cutaneous aspergillosis (PCA) occurs through direct skin inoculation via trauma, burns, or surgical wounds, with Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger as common causative species, and is rare in immunocompetent individuals. We report a case of PCA in a 56-year-old immunocompetent patient with facial and right ankle ulcers, persisting for two years. The patient had no history of diabetes, corticosteroid use, or immunodeficiency. Fungal culture and metagenomic next-generation sequencing (mNGS) confirmed A. flavus infection. Voriconazole therapy, surgical debridement, and specialized wound care led to the gradual healing of the ulcers. This case highlights the importance of early diagnosis and intervention to prevent infection spread and progression to systemic aspergillosis or septic shock.
Keywords: invasive aspergillosis, primary cutaneous aspergillosis, A. flavus, fungal infection