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已发表论文
一例结核性腹膜炎病例报告：GeneXpert 检测阴性而宏基因组测序结果阳性
Authors Yan J , Yang H, Zhang W , Li Y, Yu X, Xiong Z, Shi C, Hu Y
Received 8 September 2025
Accepted for publication 24 December 2025
Published 8 January 2026 Volume 2026:19 560202
DOI https://doi.org/10.2147/IDR.S560202
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Hazrat Bilal
Jinjin Yan,1 Huilin Yang,1 Wei Zhang,1 Yu Li,1 Xue Yu,2 Zibo Xiong,3 Chenyan Shi,2 Yunlong Hu2
1Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, School of Medicine, Shenzhen University Medical School, Shenzhen, 518055, People’s Republic of China; 3Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China
Correspondence: Yunlong Hu, Email huyunlong@szu.edu.cn Chenyan Shi, Email shichenyan9@gmail.com
Abstract: A 65-year-old male patient undergoing peritoneal dialysis was diagnosed with Mycobacterium tuberculosis-related peritonitis. Initial diagnostic tests, including acid-fast smear of ascites, GeneXpert test, and Mycobacterium tuberculosis culture, yielded negative results. However, metagenomic capture sequencing (metaCAP) and metagenomic next-generation sequencing (mNGS) identified the presence of Mycobacterium tuberculosis. The patient was subsequently treated with standard anti-tuberculosis therapy, leading to clinical improvement. This case highlights the utility of advanced molecular diagnostics in identifying atypical pathogens in peritoneal dialysis-related infections.
Keywords: tuberculous peritonitis, Mycobacterium tuberculosis, next-generation sequencing, GeneXpert
1Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Infection Immunity and Inflammation, Department of Pathogen Biology, School of Medicine, Shenzhen University Medical School, Shenzhen, 518055, People’s Republic of China; 3Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China
Correspondence: Yunlong Hu, Email huyunlong@szu.edu.cn Chenyan Shi, Email shichenyan9@gmail.com
Abstract: A 65-year-old male patient undergoing peritoneal dialysis was diagnosed with Mycobacterium tuberculosis-related peritonitis. Initial diagnostic tests, including acid-fast smear of ascites, GeneXpert test, and Mycobacterium tuberculosis culture, yielded negative results. However, metagenomic capture sequencing (metaCAP) and metagenomic next-generation sequencing (mNGS) identified the presence of Mycobacterium tuberculosis. The patient was subsequently treated with standard anti-tuberculosis therapy, leading to clinical improvement. This case highlights the utility of advanced molecular diagnostics in identifying atypical pathogens in peritoneal dialysis-related infections.
Keywords: tuberculous peritonitis, Mycobacterium tuberculosis, next-generation sequencing, GeneXpert