115563
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
溃疡性结肠炎患者的 SCCAI 和梅奥内镜严重程度评分与 QIDS-SR16 抑郁评分呈正相关
Authors Yang Z, Pang S, Jiang C, Zong Y
Received 16 October 2025
Accepted for publication 27 December 2025
Published 8 January 2026 Volume 2026:19 574826
DOI https://doi.org/10.2147/PRBM.S574826
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Igor Elman
Ziqi Yang,1,* Shu Pang,1,* Chunyan Jiang,1 Ye Zong2– 4
1Department of General Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 3National Clinical Research Center for Digestive Diseases, Beijing, People’s Republic of China; 4Beijing Key Laboratory for Early Gastrointestinal Cancer Diagnosis and Therapy, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Chunyan Jiang, Email jvo0777@yeah.net Ye Zong, Email orz2044@yeah.net
Background: Ulcerative colitis (UC) is often accompanied by depressive symptoms, yet the association between disease activity and depression remains insufficiently characterized.
Objective: To evaluate the correlations between SCCAI scores, Mayo endoscopic severity scores, and QIDS-SR16 depression scores in patients with UC.
Methods: This cross-sectional study included 106 hospitalized UC patients from January 2023 to December 2024. Disease activity was assessed using the Simple Clinical Colitis Activity Index (SCCAI), and endoscopic severity was assessed with the Mayo score in a subsample (n = 54). Depressive symptoms were evaluated using QIDS-SR16. Multivariable linear regression and restricted cubic spline models were applied to examine linear and nonlinear associations.
Results: A 1-point increase in SCCAI score was associated with a 0.41-point increase in QIDS-SR16 score (β = 0.41, 95% CI: 0.19– 0.63, P < 0.001). A 1-point increase in the Mayo score corresponded to a 1.07-point increase in QIDS-SR16 (β = 1.07, 95% CI: 0.24– 1.90, P = 0.015). Restricted cubic spline analysis revealed a nonlinear association between SCCAI and QIDS-SR16, with greater sensitivity of depressive symptoms at lower SCCAI levels.
Conclusion: In this cross-sectional real-world study, both clinical disease activity (SCCAI) and endoscopic severity (Mayo score) were independently and positively correlated with depressive symptom burden in UC patients. These findings support incorporating routine depression screening into UC clinical management to facilitate timely detection and intervention.
Keywords: ulcerative colitis, SCCAI, mayo score, depressive symptoms, QIDS-SR16
1Department of General Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 3National Clinical Research Center for Digestive Diseases, Beijing, People’s Republic of China; 4Beijing Key Laboratory for Early Gastrointestinal Cancer Diagnosis and Therapy, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Chunyan Jiang, Email jvo0777@yeah.net Ye Zong, Email orz2044@yeah.net
Background: Ulcerative colitis (UC) is often accompanied by depressive symptoms, yet the association between disease activity and depression remains insufficiently characterized.
Objective: To evaluate the correlations between SCCAI scores, Mayo endoscopic severity scores, and QIDS-SR16 depression scores in patients with UC.
Methods: This cross-sectional study included 106 hospitalized UC patients from January 2023 to December 2024. Disease activity was assessed using the Simple Clinical Colitis Activity Index (SCCAI), and endoscopic severity was assessed with the Mayo score in a subsample (n = 54). Depressive symptoms were evaluated using QIDS-SR16. Multivariable linear regression and restricted cubic spline models were applied to examine linear and nonlinear associations.
Results: A 1-point increase in SCCAI score was associated with a 0.41-point increase in QIDS-SR16 score (β = 0.41, 95% CI: 0.19– 0.63, P < 0.001). A 1-point increase in the Mayo score corresponded to a 1.07-point increase in QIDS-SR16 (β = 1.07, 95% CI: 0.24– 1.90, P = 0.015). Restricted cubic spline analysis revealed a nonlinear association between SCCAI and QIDS-SR16, with greater sensitivity of depressive symptoms at lower SCCAI levels.
Conclusion: In this cross-sectional real-world study, both clinical disease activity (SCCAI) and endoscopic severity (Mayo score) were independently and positively correlated with depressive symptom burden in UC patients. These findings support incorporating routine depression screening into UC clinical management to facilitate timely detection and intervention.
Keywords: ulcerative colitis, SCCAI, mayo score, depressive symptoms, QIDS-SR16