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已发表论文
2023 年中国重庆地区支原体肺炎所致节段/肺叶性肺炎的临床特征及危险因素探究：一项单中心住院儿童回顾性队列研究
Authors Ling Y, Zhao Y, Mei C , Deng F , Fu Z, Geng G
Received 31 October 2025
Accepted for publication 6 December 2025
Published 8 January 2026 Volume 2026:19 577148
DOI https://doi.org/10.2147/JIR.S577148
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Tara Strutt
Yaozheng Ling,1,2 Yu Zhao,1,2 Chenghao Mei,1,2 Fang Deng,1,2 Zhou Fu,1,2 Gang Geng1,2
1Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents’ Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, People’s Republic of China; 2Intelligent Application of Big Data in Pediatrics Engineering Research Center of Chongqing Education Commission of China, Chongqing, People’s Republic of China
Correspondence: Gang Geng, Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China, Email 285544470@qq.com
Purpose: Mycoplasma pneumoniae (MP)-segmental/lobar pneumonia represents a growing proportion of Mycoplasma pneumoniae pneumonia (MPP) in children. We aimed to identify the clinical characteristics and risk factors for MP-segmental/lobar pneumonia in children to facilitate early diagnosis and intervention.
Methods: We conducted a retrospective cohort study at a tertiary pediatric center in Chongqing, China, involving 1406 children hospitalized for MPP from January to December 2023. Based on imaging findings, patients were categorized into MP-ordinary pneumonia group and MP-segmental/lobar pneumonia group. Clinical data were compared, and univariate and multivariate logistic regression analyses were performed to identify independent risk factors. The predictive performance was assessed using receiver operating characteristic (ROC) curves.
Results: The MP-segmental/lobar pneumonia group exhibited a significantly longer duration of pre-admission fever, longer hospital stays, and higher rates of bronchoscopy, respiratory failure, and pulmonary complications. (all P < 0.05). Logistic regression analysis identified the following independent risk factors for MP-segmental/lobar pneumonia: sex, days with fever prior to admission, C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), platelet–lymphocyte ratio (PLR), and platelet (PLT). ROC curve analysis identified five primary predictive indicators (days with fever prior to admission > 5.5 days, D-dimer > 0.539mg/L, CRP > 11.33mg/L, LDH > 309.5U/L, PLR > 155.815) and two secondary predictive indicators (PLT > 340.5× 109/L, female sex) based on predicted efficacy. The combined use of these seven indicators further enhanced predictive performance (AUC = 0.741, 95% CI: 0.715– 0.766).
Conclusion: MP-segmental/lobar pneumonia exhibits more pronounced clinical symptoms and elevated inflammatory markers. The seven clinical indicators—days with fever prior to admission, CRP, D-dimer, LDH, PLR, PLT and female sex—serve as useful predictive markers for segmental/lobar pneumonia caused by MP. These indicators aid clinicians in the early diagnosis and intervention of MPP, thereby preventing its progression to segmental/lobar pneumonia.
Keywords: Mycoplasma pneumoniae, segmental/lobar pneumonia, clinical features, risk factors, predictive indicators
1Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents’ Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, People’s Republic of China; 2Intelligent Application of Big Data in Pediatrics Engineering Research Center of Chongqing Education Commission of China, Chongqing, People’s Republic of China
Correspondence: Gang Geng, Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, People’s Republic of China, Email 285544470@qq.com
Purpose: Mycoplasma pneumoniae (MP)-segmental/lobar pneumonia represents a growing proportion of Mycoplasma pneumoniae pneumonia (MPP) in children. We aimed to identify the clinical characteristics and risk factors for MP-segmental/lobar pneumonia in children to facilitate early diagnosis and intervention.
Methods: We conducted a retrospective cohort study at a tertiary pediatric center in Chongqing, China, involving 1406 children hospitalized for MPP from January to December 2023. Based on imaging findings, patients were categorized into MP-ordinary pneumonia group and MP-segmental/lobar pneumonia group. Clinical data were compared, and univariate and multivariate logistic regression analyses were performed to identify independent risk factors. The predictive performance was assessed using receiver operating characteristic (ROC) curves.
Results: The MP-segmental/lobar pneumonia group exhibited a significantly longer duration of pre-admission fever, longer hospital stays, and higher rates of bronchoscopy, respiratory failure, and pulmonary complications. (all P < 0.05). Logistic regression analysis identified the following independent risk factors for MP-segmental/lobar pneumonia: sex, days with fever prior to admission, C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), platelet–lymphocyte ratio (PLR), and platelet (PLT). ROC curve analysis identified five primary predictive indicators (days with fever prior to admission > 5.5 days, D-dimer > 0.539mg/L, CRP > 11.33mg/L, LDH > 309.5U/L, PLR > 155.815) and two secondary predictive indicators (PLT > 340.5× 109/L, female sex) based on predicted efficacy. The combined use of these seven indicators further enhanced predictive performance (AUC = 0.741, 95% CI: 0.715– 0.766).
Conclusion: MP-segmental/lobar pneumonia exhibits more pronounced clinical symptoms and elevated inflammatory markers. The seven clinical indicators—days with fever prior to admission, CRP, D-dimer, LDH, PLR, PLT and female sex—serve as useful predictive markers for segmental/lobar pneumonia caused by MP. These indicators aid clinicians in the early diagnosis and intervention of MPP, thereby preventing its progression to segmental/lobar pneumonia.
Keywords: Mycoplasma pneumoniae, segmental/lobar pneumonia, clinical features, risk factors, predictive indicators