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已发表论文
全身炎症反应指数（SIRI）和全身炎症指数（SII）与脑动脉粥样硬化的关联
Authors Yang C , Cai Q, Xie Y, Luo L, Huang Y, Zhang R, Liu Y
Received 9 October 2025
Accepted for publication 16 December 2025
Published 8 January 2026 Volume 2026:19 571202
DOI https://doi.org/10.2147/JIR.S571202
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Ning Quan
Chunjiao Yang,* Qi Cai,* Yu Xie, Lei Luo, Yinfei Huang, Renwei Zhang, Yumin Liu
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yumin Liu, Email ZN000187@whu.edu.cn
Background: Atherosclerosis is a chronic inflammatory disease and a leading cause of stroke. Systemic inflammatory biomarkers are recognized predictors of coronary artery disease. However, their association with cerebral atherosclerosis remains unclear. This study aims to investigate the relationship between systemic inflammatory indices and cerebral atherosclerotic burden.
Methods: A cohort of 5444 patients was enrolled. Cerebral atherosclerotic stenosis was evaluated using DSA, CTA, or MRA. The systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) were calculated and natural-log-transformed (ln-SIRI, ln-SII). The associations of ln-SIRI and ln-SII with the presence, severity (maximal stenosis degree) and extent (number of lesions) of cerebral atherosclerosis were evaluated using binary logistic regression, ordered logistic regression and restricted cubic spline models. Subgroup analyses were further conducted across clinically relevant strata to assess the consistency of these associations. Additionally, the diagnostic performance of both indices was evaluated using receiver operating characteristic (ROC) curve analysis.
Results: Patients with cerebral atherosclerotic stenosis had significantly higher ln-SIRI (OR: 1.27, 95% CI: 1.19– 1.35) and ln-SII (OR: 1.22, 95% CI: 1.15– 1.30) compared to the non-stenosis group (both p < 0.001). Both indices showed significant positive associations with the severity of the most stenotic lesion (ln-SIRI OR: 1.29, 95% CI: 1.22– 1.36; ln-SII OR: 1.26, 95% CI: 1.20– 1.33) and the number of affected sites (ln-SIRI OR: 1.27, 95% CI: 1.20– 1.34; ln-SII OR: 1.24, 95% CI: 1.18– 1.31), suggesting a significant graded association (p for trend < 0.001). Restricted cubic spline analyses revealed linear associations of ln-SIRI and ln-SII with cerebral atherosclerosis presence, severity and extent. In subgroup analyses stratified by age, comorbidities, and imaging modality, these associations remained consistent (all subgroup p < 0.05). ROC analysis indicated that both indices had modest discriminatory ability, with AUCs of 0.699 for ln-SIRI and 0.698 for ln-SII.
Conclusion: The systemic inflammatory indices ln-SIRI and ln-SII are significantly associated with the presence, severity and extent of cerebral atherosclerosis. These easily obtainable biomarkers may hold promise for improving risk stratification in cerebrovascular diseases.
Keywords: systemic immune-inflammation index, systemic inflammation response index, intracranial atherosclerosis, carotid artery diseases
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yumin Liu, Email ZN000187@whu.edu.cn
Background: Atherosclerosis is a chronic inflammatory disease and a leading cause of stroke. Systemic inflammatory biomarkers are recognized predictors of coronary artery disease. However, their association with cerebral atherosclerosis remains unclear. This study aims to investigate the relationship between systemic inflammatory indices and cerebral atherosclerotic burden.
Methods: A cohort of 5444 patients was enrolled. Cerebral atherosclerotic stenosis was evaluated using DSA, CTA, or MRA. The systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) were calculated and natural-log-transformed (ln-SIRI, ln-SII). The associations of ln-SIRI and ln-SII with the presence, severity (maximal stenosis degree) and extent (number of lesions) of cerebral atherosclerosis were evaluated using binary logistic regression, ordered logistic regression and restricted cubic spline models. Subgroup analyses were further conducted across clinically relevant strata to assess the consistency of these associations. Additionally, the diagnostic performance of both indices was evaluated using receiver operating characteristic (ROC) curve analysis.
Results: Patients with cerebral atherosclerotic stenosis had significantly higher ln-SIRI (OR: 1.27, 95% CI: 1.19– 1.35) and ln-SII (OR: 1.22, 95% CI: 1.15– 1.30) compared to the non-stenosis group (both p < 0.001). Both indices showed significant positive associations with the severity of the most stenotic lesion (ln-SIRI OR: 1.29, 95% CI: 1.22– 1.36; ln-SII OR: 1.26, 95% CI: 1.20– 1.33) and the number of affected sites (ln-SIRI OR: 1.27, 95% CI: 1.20– 1.34; ln-SII OR: 1.24, 95% CI: 1.18– 1.31), suggesting a significant graded association (p for trend < 0.001). Restricted cubic spline analyses revealed linear associations of ln-SIRI and ln-SII with cerebral atherosclerosis presence, severity and extent. In subgroup analyses stratified by age, comorbidities, and imaging modality, these associations remained consistent (all subgroup p < 0.05). ROC analysis indicated that both indices had modest discriminatory ability, with AUCs of 0.699 for ln-SIRI and 0.698 for ln-SII.
Conclusion: The systemic inflammatory indices ln-SIRI and ln-SII are significantly associated with the presence, severity and extent of cerebral atherosclerosis. These easily obtainable biomarkers may hold promise for improving risk stratification in cerebrovascular diseases.
Keywords: systemic immune-inflammation index, systemic inflammation response index, intracranial atherosclerosis, carotid artery diseases