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已发表论文
颈源性头痛的微创介入治疗：针对解剖部位的系统综述及临床疗效
Authors Jin X, Zhang Q, Lin J, Sun Y , Dong Z, Jin W
Received 24 June 2025
Accepted for publication 26 December 2025
Published 8 January 2026 Volume 2026:19 549239
DOI https://doi.org/10.2147/JPR.S549239
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rune Häckert Christensen
Xing Jin,1 Qingyu Zhang,1 Jia Lin,2 Ye Sun,3 Zhiting Dong,4 Wenzhe Jin1
1Department of Pain, Yanbian University Hospital, Yanji, Jilin, 133000, People’s Republic of China; 2Department of Internal Medicine 1, No. 965 Hospital, Jilin, Jilin, 132000, People’s Republic of China; 3Department of Anatomy, School of Medicine, Yanbian University, Yanji, Jilin, 133000, People’s Republic of China; 4Department of General Surgery II, Affiliated Hospital of Beihua University, Jilin, Jilin, 132000, People’s Republic of China
Correspondence: Wenzhe Jin, Department of Pain, Yanbian University Hospital, No. 119, Juzi Street, Yanji, Jilin, 133000, People’s Republic of China, Tel +860433-2660064, Email jinwz@ybu.edu.cn
Objective: Cervicogenic headache (CEH) is a complex secondary headache arising from functional or structural abnormalities within the cervical spine. This systematic review summarizes and evaluates the clinical effectiveness and anatomical mechanisms of minimally invasive techniques targeting sites such as the C2 dorsal root ganglion (DRG) and C1– 2 joint in CEH management..
Methods: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from January 2004 to May 2025. Studies involving minimally invasive interventions for CEH were included. Data extraction and quality appraisal were independently performed by two reviewers using the Cochrane Risk of Bias (ROB) tool and Newcastle–Ottawa Scale (NOS). Owing to heterogeneity across studies, results were narratively synthesized.
Results: Twenty-three studies were included, comprising 4 randomized controlled trials (RCTs), 13 cohort studies, 1 case-control study, and 5 anatomical studies. Interventions targeting the C2 DRG, C1– 2 joint, cervical discs, deep cervical plexus, and greater occipital nerve showed consistent short-term pain relief and improved quality of life. However, substantial heterogeneity in treatment protocols and limited long-term data restrict definitive conclusions. Most studies demonstrated moderate-to-high methodological quality.
Conclusion: This review integrates clinical and anatomical evidence to clarify how target-specific interventions influence CEH outcomes. The findings highlight the importance of anatomical precision in guiding individualized interventional strategies and provide a theoretical framework for optimizing future treatment paradigms.
Keywords: cervicogenic headache, dorsal root ganglion, radiofrequency, minimally-invasive treatments, anatomical targets, ultrasound guidance
1Department of Pain, Yanbian University Hospital, Yanji, Jilin, 133000, People’s Republic of China; 2Department of Internal Medicine 1, No. 965 Hospital, Jilin, Jilin, 132000, People’s Republic of China; 3Department of Anatomy, School of Medicine, Yanbian University, Yanji, Jilin, 133000, People’s Republic of China; 4Department of General Surgery II, Affiliated Hospital of Beihua University, Jilin, Jilin, 132000, People’s Republic of China
Correspondence: Wenzhe Jin, Department of Pain, Yanbian University Hospital, No. 119, Juzi Street, Yanji, Jilin, 133000, People’s Republic of China, Tel +860433-2660064, Email jinwz@ybu.edu.cn
Objective: Cervicogenic headache (CEH) is a complex secondary headache arising from functional or structural abnormalities within the cervical spine. This systematic review summarizes and evaluates the clinical effectiveness and anatomical mechanisms of minimally invasive techniques targeting sites such as the C2 dorsal root ganglion (DRG) and C1– 2 joint in CEH management..
Methods: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched from January 2004 to May 2025. Studies involving minimally invasive interventions for CEH were included. Data extraction and quality appraisal were independently performed by two reviewers using the Cochrane Risk of Bias (ROB) tool and Newcastle–Ottawa Scale (NOS). Owing to heterogeneity across studies, results were narratively synthesized.
Results: Twenty-three studies were included, comprising 4 randomized controlled trials (RCTs), 13 cohort studies, 1 case-control study, and 5 anatomical studies. Interventions targeting the C2 DRG, C1– 2 joint, cervical discs, deep cervical plexus, and greater occipital nerve showed consistent short-term pain relief and improved quality of life. However, substantial heterogeneity in treatment protocols and limited long-term data restrict definitive conclusions. Most studies demonstrated moderate-to-high methodological quality.
Conclusion: This review integrates clinical and anatomical evidence to clarify how target-specific interventions influence CEH outcomes. The findings highlight the importance of anatomical precision in guiding individualized interventional strategies and provide a theoretical framework for optimizing future treatment paradigms.
Keywords: cervicogenic headache, dorsal root ganglion, radiofrequency, minimally-invasive treatments, anatomical targets, ultrasound guidance