115563
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
RCII 与子宫内膜异位症之间的正相关关系及其整合入临床预测模型：一项横断面研究
Authors Wu H, Shan F, Ye M, Zhou H , Jiao J, Zhong Z, Wu Y
Received 18 September 2025
Accepted for publication 25 December 2025
Published 8 January 2026 Volume 2026:18 568706
DOI https://doi.org/10.2147/IJWH.S568706
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Vinay Kumar
Haochan Wu,1,* Fangfang Shan,1,* Mengmeng Ye,1 Hui Zhou,1,2 Jie Jiao,3 Zhaoxia Zhong,4 Yibo Wu1,2
1Human Reproductive Medicine Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Human Genetic and Reproduction Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 3Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 4Department of Obstetrics and Gynecology, Donghai People’s Hospital, Donghai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yibo Wu, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China, Email 9862016107@jiangnan.edu.cn Zhaoxia Zhong, Department of Obstetrics and Gynecology, Donghai People’s Hospital, 299Fuguo Road, Donghai, Donghai, People’s Republic of China, Email zhaoxiazzsc@163.com
Introduction: Studies indicate that endometriosis (EMs) is associated with inflammation and metabolic abnormalities. The Remnant Cholesterol Inflammatory Index (RCII) concurrently reflects both inflammatory and metabolic status. However, the relationship between RCII and EMs remains unclear. Therefore, this study aims to investigate the association between RCII and EMs and explore the potential of RCII as a risk predictor for EMs.
Methods: Making use of information from the 1999– 2006 NHANES database, we investigated the connection between natural logarithm-transformed RCII (lnRCII) and EMs employing logistic regression analysis, restricted cubic spline (RCS) models, and subgroup analysis approaches. Finally, a nomogram was constructed based on feature variables selected via LASSO regression to enhance the interpretability of the predictive model.
Results: After adjusting for potential confounding factors, lnRCII demonstrated a substantial positive correlation with the risk of EMs. For each 1-standard-deviation increase in lnRCII, the EMs’ risk increased by 25% (fully adjusted model OR = 1.250, 95% CI: 1.266– 1.461, P = 0.006). Furthermore, a linear relationship between lnRCII and EMS was observed via RCS analysis. According to subgroup analysis, the relationship between lnRCII and EMS has a consistent association across the majority of the population. (P for interaction > 0.05).
Conclusion: In the US population, RCII was substantially linked to a higher risk of EMs, suggesting that the lipid metabolism-inflammation axis may represent a potential target for intervention in the prevention or treatment of EMs.
Keywords: remnant cholesterol inflammatory index, endometriosis, cross-sectional study, NHANES
1Human Reproductive Medicine Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Human Genetic and Reproduction Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 3Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 4Department of Obstetrics and Gynecology, Donghai People’s Hospital, Donghai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yibo Wu, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China, Email 9862016107@jiangnan.edu.cn Zhaoxia Zhong, Department of Obstetrics and Gynecology, Donghai People’s Hospital, 299Fuguo Road, Donghai, Donghai, People’s Republic of China, Email zhaoxiazzsc@163.com
Introduction: Studies indicate that endometriosis (EMs) is associated with inflammation and metabolic abnormalities. The Remnant Cholesterol Inflammatory Index (RCII) concurrently reflects both inflammatory and metabolic status. However, the relationship between RCII and EMs remains unclear. Therefore, this study aims to investigate the association between RCII and EMs and explore the potential of RCII as a risk predictor for EMs.
Methods: Making use of information from the 1999– 2006 NHANES database, we investigated the connection between natural logarithm-transformed RCII (lnRCII) and EMs employing logistic regression analysis, restricted cubic spline (RCS) models, and subgroup analysis approaches. Finally, a nomogram was constructed based on feature variables selected via LASSO regression to enhance the interpretability of the predictive model.
Results: After adjusting for potential confounding factors, lnRCII demonstrated a substantial positive correlation with the risk of EMs. For each 1-standard-deviation increase in lnRCII, the EMs’ risk increased by 25% (fully adjusted model OR = 1.250, 95% CI: 1.266– 1.461, P = 0.006). Furthermore, a linear relationship between lnRCII and EMS was observed via RCS analysis. According to subgroup analysis, the relationship between lnRCII and EMS has a consistent association across the majority of the population. (P for interaction > 0.05).
Conclusion: In the US population, RCII was substantially linked to a higher risk of EMs, suggesting that the lipid metabolism-inflammation axis may represent a potential target for intervention in the prevention or treatment of EMs.
Keywords: remnant cholesterol inflammatory index, endometriosis, cross-sectional study, NHANES