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已发表论文
EGFL7 基因多态性及表达与宫颈癌易感性及发病机制的相关性研究
Authors Liu W , Niu Z, Yan Z, Shi L, Zhang S, Hong C, Dai S, Shi L, Yao Y
Received 27 August 2025
Accepted for publication 19 December 2025
Published 8 January 2026 Volume 2026:19 563592
DOI https://doi.org/10.2147/IJGM.S563592
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Ching-Hsien Chen
Weipeng Liu,1,2,* Zhixin Niu,1,* Zhiling Yan,3 Lei Shi,1 Shao Zhang,3 Chao Hong,1 Shuying Dai,4 Li Shi,1 Yufeng Yao1
1Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People’s Republic of China; 2Department of Orthopedics, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology Affliated Hospital; the Key Laboratory of Digital Orthopedics of Yunnan Province; the Clinical Medicine Center of Spinal and Spinal Cord Disorders of Yunnan Province, Kunming, People’s Republic of China; 3Department of Gynaecologic Oncology, No.3 Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 4Department of Pathogen Biology and Immunology Faculty of Basic Medical Science, Kunming Medical University, Kunming, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Li Shi; Yufeng Yao, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People’s Republic of China, Email shili.imb@gmail.com; leoyyf@gmail.com
Purpose: Previous studies have highlighted diverse roles for EGFL7 in various cancers, but its specific function in cervical cancer remains unclear. This study aimed to elucidate the role of EGFL7 in cervical cancer susceptibility and pathogenesis.
Methods: We genotyped three EGFL7 SNPs in 694 healthy controls, 408 cervical intraepithelial neoplasia (CIN) patients, and 934 cervical cancer (CC) patients using TaqMan probe-based real-time PCR. EGFL7 expression was measured in tumor tissues and cell lines via qRT-PCR. RNA sequencing was used to explore the biological functions of EGFL7 in cervical cancer.
Results: The G allele frequency of rs9411260 was significantly elevated in both the cervical cancer (CC) (P = 0.006) and cervical intraepithelial neoplasia (CIN) (P = 0.016) groups compared to the control group. EGFL7 mRNA expression was markedly downregulated in cervical cancer tissues and HeLa/C33A cells compared to normal tissues and ECT1/E6E7 cells. Furthermore, modulation of EGFL7 expression was found to alter pathways associated with cell adhesion, migration, and ECM-receptor interaction.
Conclusion: EGFL7 polymorphisms and expression are associated with cervical cancer susceptibility. Dysregulated EGFL7 appears to contribute to cervical cancer progression by affecting cell adhesion and migration, offering new insights into its pathogenesis and potential therapeutic targets.
Keywords: EGFL7, SNPs, cervical cancer, cell adhesion, migration
1Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People’s Republic of China; 2Department of Orthopedics, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology Affliated Hospital; the Key Laboratory of Digital Orthopedics of Yunnan Province; the Clinical Medicine Center of Spinal and Spinal Cord Disorders of Yunnan Province, Kunming, People’s Republic of China; 3Department of Gynaecologic Oncology, No.3 Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China; 4Department of Pathogen Biology and Immunology Faculty of Basic Medical Science, Kunming Medical University, Kunming, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Li Shi; Yufeng Yao, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, People’s Republic of China, Email shili.imb@gmail.com; leoyyf@gmail.com
Purpose: Previous studies have highlighted diverse roles for EGFL7 in various cancers, but its specific function in cervical cancer remains unclear. This study aimed to elucidate the role of EGFL7 in cervical cancer susceptibility and pathogenesis.
Methods: We genotyped three EGFL7 SNPs in 694 healthy controls, 408 cervical intraepithelial neoplasia (CIN) patients, and 934 cervical cancer (CC) patients using TaqMan probe-based real-time PCR. EGFL7 expression was measured in tumor tissues and cell lines via qRT-PCR. RNA sequencing was used to explore the biological functions of EGFL7 in cervical cancer.
Results: The G allele frequency of rs9411260 was significantly elevated in both the cervical cancer (CC) (P = 0.006) and cervical intraepithelial neoplasia (CIN) (P = 0.016) groups compared to the control group. EGFL7 mRNA expression was markedly downregulated in cervical cancer tissues and HeLa/C33A cells compared to normal tissues and ECT1/E6E7 cells. Furthermore, modulation of EGFL7 expression was found to alter pathways associated with cell adhesion, migration, and ECM-receptor interaction.
Conclusion: EGFL7 polymorphisms and expression are associated with cervical cancer susceptibility. Dysregulated EGFL7 appears to contribute to cervical cancer progression by affecting cell adhesion and migration, offering new insights into its pathogenesis and potential therapeutic targets.
Keywords: EGFL7, SNPs, cervical cancer, cell adhesion, migration