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已发表论文
小胶质细胞极化：神经病理性疼痛的关键调节机制
Authors Zhang T , Liang W, Gao J, Liu H, Li J, Chen J, Wang Y, Li J
Received 30 July 2025
Accepted for publication 18 December 2025
Published 8 January 2026 Volume 2026:19 557153
DOI https://doi.org/10.2147/JPR.S557153
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Alaa Abd-Elsayed
Tianrui Zhang,1– 4 Wulin Liang,5 Jie Gao,1– 4 Huan Liu,1– 4 Jianhua Li,1– 4 Jianhua Chen,1– 4 Yuhao Wang,1– 4 Jianguo Li4
1Shanxi Provincial Key Laboratory of Drug Toxicology and Preclinical Research of Radiopharmaceuticals, Taiyuan, Shanxi, People’s Republic of China; 2Key Laboratory of Radiotoxicology and Preclinical Evaluation of Radiopharmaceuticals, Taiyuan, Shanxi, People’s Republic of China; 3National Atomic Energy Agency Nuclear Technology Research and Development Center, Taiyuan, Shanxi, People’s Republic of China; 4Institute of Radiology and Environmental Medicine, China Institute for Radiation Protection, Taiyuan, Shanxi, People’s Republic of China; 5Leiyunshang Pharmaceutical Group Co., Ltd, Suzhou, Nanjing, People’s Republic of China
Correspondence: Jianguo Li, Institute of Radiology and Environmental Medicine, China Institute for Radiation Protection, No. 102, Xuefu Street, Taiyuan, Shanxi, People’s Republic of China, Tel +86-0351-2202231, Email LJG2547@163.com
Abstract: Neuropathic pain is a chronic pain syndrome resulting from damage or dysfunction to the somatosensory nervous system, significantly impairing patients’ quality of life. Microglia play a crucial role in the development and maintenance of neuropathic pain, particularly through their polarization mechanisms. This review summarizes the regulatory mechanisms underlying microglial polarization in neuropathic pain, the associated signaling pathways, pharmacological agents that modulate microglial polarization, and intervention strategies targeting neuropathic pain. We emphasize the intrinsic link between microglial polarization and neuropathic pain, aiming to identify potential therapeutic targets and provide a scientific basis for drug development and preclinical research in the treatment of neuropathic pain.
Keywords: neuropathic pain, microglia, polarization
1Shanxi Provincial Key Laboratory of Drug Toxicology and Preclinical Research of Radiopharmaceuticals, Taiyuan, Shanxi, People’s Republic of China; 2Key Laboratory of Radiotoxicology and Preclinical Evaluation of Radiopharmaceuticals, Taiyuan, Shanxi, People’s Republic of China; 3National Atomic Energy Agency Nuclear Technology Research and Development Center, Taiyuan, Shanxi, People’s Republic of China; 4Institute of Radiology and Environmental Medicine, China Institute for Radiation Protection, Taiyuan, Shanxi, People’s Republic of China; 5Leiyunshang Pharmaceutical Group Co., Ltd, Suzhou, Nanjing, People’s Republic of China
Correspondence: Jianguo Li, Institute of Radiology and Environmental Medicine, China Institute for Radiation Protection, No. 102, Xuefu Street, Taiyuan, Shanxi, People’s Republic of China, Tel +86-0351-2202231, Email LJG2547@163.com
Abstract: Neuropathic pain is a chronic pain syndrome resulting from damage or dysfunction to the somatosensory nervous system, significantly impairing patients’ quality of life. Microglia play a crucial role in the development and maintenance of neuropathic pain, particularly through their polarization mechanisms. This review summarizes the regulatory mechanisms underlying microglial polarization in neuropathic pain, the associated signaling pathways, pharmacological agents that modulate microglial polarization, and intervention strategies targeting neuropathic pain. We emphasize the intrinsic link between microglial polarization and neuropathic pain, aiming to identify potential therapeutic targets and provide a scientific basis for drug development and preclinical research in the treatment of neuropathic pain.
Keywords: neuropathic pain, microglia, polarization