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已发表论文
甘油三酯葡萄糖指数和心外膜脂肪组织与 2 型糖尿病合并冠状动脉粥样硬化性心脏病的相关性
Authors Liu B, Du J, Niu Z , Lu Q
Received 16 October 2025
Accepted for publication 11 December 2025
Published 8 January 2026 Volume 2026:19 566381
DOI https://doi.org/10.2147/DMSO.S566381
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Jae Woong Sull
Binbin Liu,1 Juan Du,2 Ziru Niu,3 Qiang Lu3
1Department of Functional Examination, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China; 2Department of Imaging, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China; 3Department of Endocrinology, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China
Correspondence: Qiang Lu, Department of Endocrinology, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China, Tel +86 13933909066, Email 13933909066@126.com
Background: To examine the role of the triglyceride glucose(TyG) index and epicardial adipose tissue(EAT) in the progression of type 2 diabetes mellitus (T2DM) with concurrent coronary atherosclerotic heart disease(CHD), thereby establishing a theoretical foundation for early clinical intervention in CHD among T2DM patients.
Methods: This retrospective study analysed 96 patients with T2DM who underwent Coronary CT angiography at the Department of Endocrinology, Qinhuangdao First Hospital, between January 2020 and June 2023. Participants were categorised into two groups: those with T2DM and CHD (n=48) and those with T2DM alone (n=48). Clinical indicators were compared between the groups. Logistic regression analysis assessed the association between T2DM with CHD and both the TyG index and EAT. Receiver operating characteristic (ROC) curve analysis evaluated the predictive value of these parameters.
Results: Significant differences (P < 0.05) were found between the two groups in weight, uric acid(UA), triglycerides(TG), high-density lipoprotein cholesterol (HDL-C), epicardial adipose tissue volume (EATV) and the TyG index. Multivariate analysis identified both EATV and the TyG index as independent risk factors for T2DM complicated by CHD (P < 0.05). ROC curve analysis demonstrated that both EATV and TyG index showed statistically significant predictive power for CHD development in T2DM patients (P< 0.05). The EATV exhibited an AUC of 0.739 with a predictive cut-off value of 128.45 mL (sensitivity 66.7%, specificity 72.9%). The TyG index demonstrated an AUC of 0.724 with a predictive cut-off value of 9.47 (sensitivity 58.3%, specificity 81.2%).
Conclusion: The TyG index and EAT are significant risk factors for CHD in T2DM patients. These findings provide a theoretical basis for early screening, monitoring, and clinical intervention in this population.
Keywords: triglyceride glucose index, epicardial adipose tissue, type 2 diabetes mellitus, coronary atherosclerotic heart disease
1Department of Functional Examination, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China; 2Department of Imaging, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China; 3Department of Endocrinology, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China
Correspondence: Qiang Lu, Department of Endocrinology, First Hospital of Qinhuangdao, Hebei, Qinhuangdao, 066000, People’s Republic of China, Tel +86 13933909066, Email 13933909066@126.com
Background: To examine the role of the triglyceride glucose(TyG) index and epicardial adipose tissue(EAT) in the progression of type 2 diabetes mellitus (T2DM) with concurrent coronary atherosclerotic heart disease(CHD), thereby establishing a theoretical foundation for early clinical intervention in CHD among T2DM patients.
Methods: This retrospective study analysed 96 patients with T2DM who underwent Coronary CT angiography at the Department of Endocrinology, Qinhuangdao First Hospital, between January 2020 and June 2023. Participants were categorised into two groups: those with T2DM and CHD (n=48) and those with T2DM alone (n=48). Clinical indicators were compared between the groups. Logistic regression analysis assessed the association between T2DM with CHD and both the TyG index and EAT. Receiver operating characteristic (ROC) curve analysis evaluated the predictive value of these parameters.
Results: Significant differences (P < 0.05) were found between the two groups in weight, uric acid(UA), triglycerides(TG), high-density lipoprotein cholesterol (HDL-C), epicardial adipose tissue volume (EATV) and the TyG index. Multivariate analysis identified both EATV and the TyG index as independent risk factors for T2DM complicated by CHD (P < 0.05). ROC curve analysis demonstrated that both EATV and TyG index showed statistically significant predictive power for CHD development in T2DM patients (P< 0.05). The EATV exhibited an AUC of 0.739 with a predictive cut-off value of 128.45 mL (sensitivity 66.7%, specificity 72.9%). The TyG index demonstrated an AUC of 0.724 with a predictive cut-off value of 9.47 (sensitivity 58.3%, specificity 81.2%).
Conclusion: The TyG index and EAT are significant risk factors for CHD in T2DM patients. These findings provide a theoretical basis for early screening, monitoring, and clinical intervention in this population.
Keywords: triglyceride glucose index, epicardial adipose tissue, type 2 diabetes mellitus, coronary atherosclerotic heart disease