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已发表论文
作为光动力免疫调节剂的金丝桃素：一种用于皮肤科治疗的天然化合物
Authors Ma H, Zhang X, Li R, Qu B, Liu Y, Cui Y, Zhang T, Zhao J
Received 6 August 2025
Accepted for publication 17 November 2025
Published 8 January 2026 Volume 2026:20 558923
DOI https://doi.org/10.2147/DDDT.S558923
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Anastasios Lymperopoulos
Huike Ma,* Xiawei Zhang,* Ruonan Li,* Baoquan Qu, Yuchen Liu, Yunran Cui, Tianlu Zhang, Jingxia Zhao
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jingxia Zhao, Email zhaojingxia@bjzhongyi.com
Abstract: Hypericin, a polycyclic quinone derived from *Hypericum perforatum* (St. John’s Wort), has gained attention for its broad pharmacological activities, including anti-inflammatory, antimicrobial, and antitumor effects. It modulates key signaling pathways like NF-κB and MAPK, reducing chronic inflammation and making it effective in treating autoimmune and infectious skin conditions. As a photosensitizer, hypericin also induces apoptosis in abnormal cells through photodynamic therapy (PDT), showing promising results in treating cutaneous T-cell lymphoma (CTCL), psoriasis, and fungal infections. While its solubility and bioavailability remain challenges, hypericin’s favorable safety profile and therapeutic potential position it as a valuable option for managing refractory dermatological conditions.
Keywords: hypericin, anti-inflammatory, PDT, ROS, psoriasis, CTCL
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, 100010, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jingxia Zhao, Email zhaojingxia@bjzhongyi.com
Abstract: Hypericin, a polycyclic quinone derived from *Hypericum perforatum* (St. John’s Wort), has gained attention for its broad pharmacological activities, including anti-inflammatory, antimicrobial, and antitumor effects. It modulates key signaling pathways like NF-κB and MAPK, reducing chronic inflammation and making it effective in treating autoimmune and infectious skin conditions. As a photosensitizer, hypericin also induces apoptosis in abnormal cells through photodynamic therapy (PDT), showing promising results in treating cutaneous T-cell lymphoma (CTCL), psoriasis, and fungal infections. While its solubility and bioavailability remain challenges, hypericin’s favorable safety profile and therapeutic potential position it as a valuable option for managing refractory dermatological conditions.
Keywords: hypericin, anti-inflammatory, PDT, ROS, psoriasis, CTCL