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已发表论文
人乳头瘤病毒诱导的卵巢囊性畸胎瘤角化鳞状细胞癌：一例报告及文献综述
Authors Zhang H, Feng J, Guo Q, Liu J, Zhan P
Received 28 September 2025
Accepted for publication 30 December 2025
Published 8 January 2026 Volume 2026:18 570899
DOI https://doi.org/10.2147/IJWH.S570899
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Everett Magann
Hanrui Zhang,1 Jia Feng,2 Qian Guo,1 Jinbo Liu,2 Ping Zhan1
1Department of Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China
Correspondence: Ping Zhan, Email zpsclz@126.com
Abstract: Ovarian mature cystic teratoma (MCT), the most common ovarian tumor, undergoes malignant transformation only in a small proportion of cases, most frequently into squamous cell carcinoma. However, malignant transformation into squamous cell carcinoma associated with human papillomavirus (HPV) infection is exceptionally rare. Here, we reported a 43-year-old premenopausal woman who presented with an abdominal mass. CT examination suggested an ovarian MCT, and then the patient underwent surgical resection. Histopathological analysis confirmed a diagnosis of MCT-derived keratinizing squamous cell carcinoma, with HPV types 16 and 59 infections being detected through preoperative cervical cancer screening. According to the 2014 FIGO staging system, the patient was diagnosed as stage IC. The surgery was successful, and adjuvant chemotherapy with the BEP regimen was planned. Notably, malignant transformation of MCT is uncommon, and HPV-related squamous cell carcinoma arising from an ovarian teratoma is scarcely documented. This case highlights the importance of considering malignant transformation in clinical practice, particularly through early assessment based on patient age, tumor size, and tumor marker levels, to ensure timely diagnosis and intervention.
Keywords: mature cystic teratoma, malignant transformation, squamous cell carcinoma, human papillomavirus
1Department of Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China
Correspondence: Ping Zhan, Email zpsclz@126.com
Abstract: Ovarian mature cystic teratoma (MCT), the most common ovarian tumor, undergoes malignant transformation only in a small proportion of cases, most frequently into squamous cell carcinoma. However, malignant transformation into squamous cell carcinoma associated with human papillomavirus (HPV) infection is exceptionally rare. Here, we reported a 43-year-old premenopausal woman who presented with an abdominal mass. CT examination suggested an ovarian MCT, and then the patient underwent surgical resection. Histopathological analysis confirmed a diagnosis of MCT-derived keratinizing squamous cell carcinoma, with HPV types 16 and 59 infections being detected through preoperative cervical cancer screening. According to the 2014 FIGO staging system, the patient was diagnosed as stage IC. The surgery was successful, and adjuvant chemotherapy with the BEP regimen was planned. Notably, malignant transformation of MCT is uncommon, and HPV-related squamous cell carcinoma arising from an ovarian teratoma is scarcely documented. This case highlights the importance of considering malignant transformation in clinical practice, particularly through early assessment based on patient age, tumor size, and tumor marker levels, to ensure timely diagnosis and intervention.
Keywords: mature cystic teratoma, malignant transformation, squamous cell carcinoma, human papillomavirus