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已发表论文
2 型糖尿病患者中甘油三酯葡萄糖-体重指数与骨质疏松症呈线性负相关：一项横断面研究
Authors Zhou L, Zhang F, Wang Z, Kang Z
Received 24 September 2025
Accepted for publication 23 December 2025
Published 6 January 2026 Volume 2026:19 569521
DOI https://doi.org/10.2147/DMSO.S569521
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Lingfan Zhou,1,2 Fengjiao Zhang,2 Zhenwei Wang,3 Zhiqiang Kang2
1Department of Endocrinology, Henan Medical University Affiliated Zhengzhou Central Hospital, Zhengzhou, 450000, People’s Republic of China; 2Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China
Correspondence: Zhenwei Wang, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China, Email zhenweiwang@zzu.edu.cn Zhiqiang Kang, Department of Endocrinology, Affiliated Central Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China, Email kzq9229@163.com
Aim: This study was to evaluate the association between triglyceride glucose-body mass index (TyG-BMI) and osteoporosis in patients with type 2 diabetes mellitus (T2DM).
Methods: In this cross-sectional study, 892 patients with T2DM hospitalized at Zhengrzhou Central Hospital between April 2024 and March 2025 were included. Participants were grouped into TyG-BMI tertiles (T1 ≤ 209.31, T2 209.31– 243.39, T3 > 243.39). Logistic regression analysis, subgroup and sensitivity analyses, receiver operating characteristic (ROC) curve analysis, and restricted cubic spline (RCS) modeling were performed to evaluate the relationship between TyG-BMI and osteoporosis.
Results: After adjusting for potential confounders, each one-unit increase in TyG-BMI was associated with a 1.5% lower odds of osteoporosis (OR = 0.985, 95% CI: 0.978– 0.992). Compared with T1, the odds of osteoporosis were significantly reduced in T2 and T3 (T2: OR = 0.565, 95% CI: 0.352– 0.908; T3: OR = 0.322, 95% CI: 0.167– 0.620). Subgroup analyses confirmed that the inverse association remained stable across most demographic and clinical strata. Sensitivity analyses further supported this trend: participants in the highest TyG-BMI quartile had a 74.8% lower risk of osteoporosis compared with those in the lowest quartile. Individuals with TyG-BMI above the median also showed a markedly reduced osteoporosis risk. ROC analysis showed TyG-BMI had a higher predictive value (AUC = 0.657) for osteoporosis than TyG index (AUC = 0.554) or BMI (AUC = 0.647) alone. RCS analysis indicated a significant linear negative relationship without evidence of nonlinearity (P for nonlinearity = 0.720).
Conclusion: Higher TyG-BMI levels are inversely associated with the risk of osteoporosis in patients with T2DM.
Keywords: insulin resistance, triglyceride-glucose index, triglyceride glucose-body mass index, osteoporosis, type 2 diabetes mellitus
1Department of Endocrinology, Henan Medical University Affiliated Zhengzhou Central Hospital, Zhengzhou, 450000, People’s Republic of China; 2Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China
Correspondence: Zhenwei Wang, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China, Email zhenweiwang@zzu.edu.cn Zhiqiang Kang, Department of Endocrinology, Affiliated Central Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China, Email kzq9229@163.com
Aim: This study was to evaluate the association between triglyceride glucose-body mass index (TyG-BMI) and osteoporosis in patients with type 2 diabetes mellitus (T2DM).
Methods: In this cross-sectional study, 892 patients with T2DM hospitalized at Zhengrzhou Central Hospital between April 2024 and March 2025 were included. Participants were grouped into TyG-BMI tertiles (T1 ≤ 209.31, T2 209.31– 243.39, T3 > 243.39). Logistic regression analysis, subgroup and sensitivity analyses, receiver operating characteristic (ROC) curve analysis, and restricted cubic spline (RCS) modeling were performed to evaluate the relationship between TyG-BMI and osteoporosis.
Results: After adjusting for potential confounders, each one-unit increase in TyG-BMI was associated with a 1.5% lower odds of osteoporosis (OR = 0.985, 95% CI: 0.978– 0.992). Compared with T1, the odds of osteoporosis were significantly reduced in T2 and T3 (T2: OR = 0.565, 95% CI: 0.352– 0.908; T3: OR = 0.322, 95% CI: 0.167– 0.620). Subgroup analyses confirmed that the inverse association remained stable across most demographic and clinical strata. Sensitivity analyses further supported this trend: participants in the highest TyG-BMI quartile had a 74.8% lower risk of osteoporosis compared with those in the lowest quartile. Individuals with TyG-BMI above the median also showed a markedly reduced osteoporosis risk. ROC analysis showed TyG-BMI had a higher predictive value (AUC = 0.657) for osteoporosis than TyG index (AUC = 0.554) or BMI (AUC = 0.647) alone. RCS analysis indicated a significant linear negative relationship without evidence of nonlinearity (P for nonlinearity = 0.720).
Conclusion: Higher TyG-BMI levels are inversely associated with the risk of osteoporosis in patients with T2DM.
Keywords: insulin resistance, triglyceride-glucose index, triglyceride glucose-body mass index, osteoporosis, type 2 diabetes mellitus