115563
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
核酸药物的靶向递送：新兴载体及其在常见代谢与炎症性疾病中的应用
Authors Lin X, Chen L, Jia K, Li S, Li Q, Yi J , Xing J
Received 10 September 2025
Accepted for publication 11 December 2025
Published 15 January 2026 Volume 2026:21 566642
DOI https://doi.org/10.2147/IJN.S566642
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Kamakhya Misra
Xiyuan Lin,1,* Li Chen,2,* Keran Jia,3,* Shengbiao Li,4 Qiuhong Li,5 Jingyan Yi,1 Jinshan Xing6
1Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Key Laboratory of Medical Electrophysiology, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 3Department of Health Services and Management, School of Health Care Technology, Chengdu Neusoft University, Chengdu, Sichuan, 610000, People’s Republic of China; 4Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 5Department of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 6Department of Neurosurgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jinshan Xing; Jingyan Yi, Email xingjinshan2020@swmu.edu.cn; jingyany@swmu.edu.cn
摘要：基因组学与分子生物学的最新进展加速了基于核酸的治疗药物的开发。为优化其临床疗效，研究者们探索了多种递送系统，包括脂质纳米粒、聚合物纳米材料、无机纳米颗粒、细胞外囊泡、病毒载体、蛋白质载体以及核酸偶联物，旨在提高核酸药物的稳定性、细胞摄取率和生物利用度。本文综述了核酸治疗药物的现状，重点阐述其分类、递送策略以及在代谢性和炎症性疾病中的应用。文章着重分析了这些递送系统的作用机制、靶向递送方法以及当前面临的挑战。文献检索自PubMed和Web of Science数据库，筛选标准包括与主题的相关性及发表时间（2020-2025年）。本文旨在为优化核酸药物及开发新型递送系统提供见解，为复杂疾病的治疗提供新的视角。
1Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education, Key Laboratory of Medical Electrophysiology, Ministry of Education, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 3Department of Health Services and Management, School of Health Care Technology, Chengdu Neusoft University, Chengdu, Sichuan, 610000, People’s Republic of China; 4Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Key Laboratory of Medical Electrophysiology, Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 5Department of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 6Department of Neurosurgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jinshan Xing; Jingyan Yi, Email xingjinshan2020@swmu.edu.cn; jingyany@swmu.edu.cn
摘要：基因组学与分子生物学的最新进展加速了基于核酸的治疗药物的开发。为优化其临床疗效，研究者们探索了多种递送系统，包括脂质纳米粒、聚合物纳米材料、无机纳米颗粒、细胞外囊泡、病毒载体、蛋白质载体以及核酸偶联物，旨在提高核酸药物的稳定性、细胞摄取率和生物利用度。本文综述了核酸治疗药物的现状，重点阐述其分类、递送策略以及在代谢性和炎症性疾病中的应用。文章着重分析了这些递送系统的作用机制、靶向递送方法以及当前面临的挑战。文献检索自PubMed和Web of Science数据库，筛选标准包括与主题的相关性及发表时间（2020-2025年）。本文旨在为优化核酸药物及开发新型递送系统提供见解，为复杂疾病的治疗提供新的视角。