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已发表论文
基于光合作用启发的跨物种可植入式ATP电池及其在疾病治疗中的应用
Authors Chen M, Zhang W, Qu B, Huang X
Received 20 September 2025
Accepted for publication 6 January 2026
Published 14 January 2026 Volume 2026:21 569114
DOI https://doi.org/10.2147/IJN.S569114
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Yan Shen
Maike Chen,1,2,* Weiyue Zhang,3,* Baicheng Qu,1,2 Xin Huang1,2
1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of China; 3Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China
*These authors contributed equally to this work
Correspondence: At, Weiyue Zhang, Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email zhangweiyuehust@163.com Xin Huang, Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email xin_huang@hust.edu.cn
细胞能量与还原当量的不足，会严重破坏生理稳态，削弱机体固有的修复机制，这是治疗许多疾病面临的主要挑战。本文旨在探讨一种受光合作用启发的跨物种可植入式ATP电池及其在疾病治疗中的应用。该技术旨在受损的人体细胞内自主再生ATP，直接对抗疾病进展背后的代谢缺陷。我们系统地阐述了该人工光合系统的三个基础组成部分：光氧化模块，负责将光能转化为电化学质子梯度；光合磷酸化模块，利用该梯度驱动ATP合成；以及封装系统，其对空间组织、功能完整性和靶向细胞递送至关重要。这些模块的协同运作，使得在人体细胞内实现持续、光驱动的ATP生产成为可能，从而在细胞水平上建立了一种对自然光合作用的功能性模拟。此外，我们评估了该技术平台在不同病理背景下的治疗可行性，包括肿瘤缺氧微环境、代谢受损的组织再生以及能量不足的神经元。该平台整合了合成生物学、材料科学和靶向递送策略。通过直接恢复细胞生物能量并促进修复过程，它在治疗多种疾病方面具有变革性潜力。因此，这标志着向建立代谢重编程和精准能量恢复作为人类疾病核心临床治疗模式迈出的开创性一步。
1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Key Laboratory of Regenerative Medicine and Multi-Disciplinary Translational Research, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of China; 3Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China
*These authors contributed equally to this work
Correspondence: At, Weiyue Zhang, Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email zhangweiyuehust@163.com Xin Huang, Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Email xin_huang@hust.edu.cn
细胞能量与还原当量的不足，会严重破坏生理稳态，削弱机体固有的修复机制，这是治疗许多疾病面临的主要挑战。本文旨在探讨一种受光合作用启发的跨物种可植入式ATP电池及其在疾病治疗中的应用。该技术旨在受损的人体细胞内自主再生ATP，直接对抗疾病进展背后的代谢缺陷。我们系统地阐述了该人工光合系统的三个基础组成部分：光氧化模块，负责将光能转化为电化学质子梯度；光合磷酸化模块，利用该梯度驱动ATP合成；以及封装系统，其对空间组织、功能完整性和靶向细胞递送至关重要。这些模块的协同运作，使得在人体细胞内实现持续、光驱动的ATP生产成为可能，从而在细胞水平上建立了一种对自然光合作用的功能性模拟。此外，我们评估了该技术平台在不同病理背景下的治疗可行性，包括肿瘤缺氧微环境、代谢受损的组织再生以及能量不足的神经元。该平台整合了合成生物学、材料科学和靶向递送策略。通过直接恢复细胞生物能量并促进修复过程，它在治疗多种疾病方面具有变革性潜力。因此，这标志着向建立代谢重编程和精准能量恢复作为人类疾病核心临床治疗模式迈出的开创性一步。