Mingjing Xu,1,* Lijun Xiong,2,* Zhenjuan Qin,3,* Xinyi Yu,4,* Tao Chen,4,* Xinxin Zhang,1,* Mingyue Jin,5,* Liping Wang,2,* Longqiang Cai,3,* Yuhua Wei,3,* Huihua Liu,3,* Chengqiang Wang,2 Huilin Hu,3,* Zhenyou Zou1,3– 5 

1School of Public Health, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2College of Biotechnology, Guilin Medical University, Guilin, Guangxi, People’s Republic of China; 3Key Laboratory of Mental Disorders and Prevention, Guangxi Zhuang Autonomous Region Brain Hospital, Liuzhou, Guangxi, People’s Republic of China; 4School of Public Health, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, People’s Republic of China; 5Department of Genetic Disease Research, Osaka Metropolitan University, Osaka, Japan

*These authors contributed equally to this work

Correspondence: Zhenyou Zou, Email sokuren@163.com Chengqiang Wang, Email 357535605@qq.com
摘要：随着社会的老龄化，阿尔茨海默病（AD）患者数量也在急速增加，给家庭和社会带来了沉重的负担。本文综述了AD的病因，特别是与AD相关的表观遗传学改变，包括DNA甲基化、组蛋白修饰和非编码RNA改变。讨论了基于表观遗传变化特异性标志物的诊断试剂的开发，以及干预不良表观遗传因素变化治疗AD的尝试。以帮助人们理解表观遗传学与AD的关系，为人们探索AD的诊断和治疗策略提供指导。