德孚在中国

115563

论文已发表

提 交 论 文


注册即可获取德孚的最新动态

注 册



IF 收录期刊





更多详情 >>





QR Code

已发表论文

n-3与n-6多不饱和脂肪酸在慢性阻塞性肺疾病炎症中的作用及机制

 

Authors Wang Y , Bao Y, Liu B, Li H, Duan H, Wang Y , Zhang J, Wu W , Li P, Liu X

Received 25 July 2025

Accepted for publication 5 January 2026

Published 15 January 2026 Volume 2026:19 556221

DOI https://doi.org/10.2147/JIR.S556221

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Yuhan Xing

Yingqi Wang,1,* Yidie Bao,1,* Boya Liu,1,* Hui Li,1 Hongxia Duan,1 Yide Wang,2 Jiachi Zhang,1 Weibing Wu,3 Peijun Li,1 Xiaodan Liu1 

1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Rehabilitation, The Fourth Clinical Medical College of Xinjiang Medical University, Urumqi, People’s Republic of China; 3School of Exercise and Health, Shanghai University of Sport, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xiaodan Liu, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Cailun Road No. 1200, Pudong New Distinct, Shanghai, 201203, People’s Republic of China, Email hzhp403@126.com Peijun Li, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Cailun Road No. 1200, Pudong New Distinct, Shanghai, 201203, People’s Republic of China, Email lpj0227@163.com
摘要

慢性阻塞性肺疾病（COPD）目前仍然是全球死亡的主要原因之一。慢性炎症是COPD关键发病机制。因此，开发COPD炎症的有效治疗策略，对于降低COPD患病率、死亡率和总体负担至关重要。多不饱和脂肪酸（PUFAs）因具有调节炎症的作用而受到关注，可能影响炎症相关疾病。本综述对COPD患者PUFAs的观察性和干预性研究进行评估，并阐明PUFAs影响COPD炎症的潜在机制。文献综合分析显示，PUFAs与COPD关联的证据有限且不一致。目前缺乏有力数据来确切证明n-3 PUFAs对COPD的生物学益处和临床疗效。因此，我们对当前研究进行系统评估，并建议未来开展广泛且严格的临床试验。此外，PUFAs及其衍生物可以通过直接参与、调节巨噬细胞极化以及影响膜生物物理学和信号转导，在COPD炎症引发和消退中发挥作用。尽管目前证据尚不明确，但我们认为有必要针对COPD患者加强PUFAs的临床试验和药物研发工作，以制定新的治疗策略。
Download Article[PDF]