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已发表论文
早产胎膜早破（PPROM）对母婴结局的影响及应对措施分析
Authors Chen Y, Zhou D , Tu Y, Wang Y
Received 11 June 2025
Accepted for publication 23 November 2025
Published 15 January 2026 Volume 2026:18 534571
DOI https://doi.org/10.2147/IJWH.S534571
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Everett Magann
Yaoyao Chen, Dehua Zhou, Yiyu Tu, Yurong Wang
Department of Pediatric, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325200, People’s Republic of China
Correspondence: Dehua Zhou, Email qcyx567@163.com
Objective: This study aimed to analyze the risk factors for Preterm Premature Rupture of Membranes (PPROM) and evaluate the impact of the timing of antibiotic administration on maternal and neonatal outcomes.
Methods: A retrospective cohort study was conducted involving 480 pregnant women (240 with PPROM and 240 without PPROM) hospitalized between January 2021 and December 2022. Maternal data, genital microbiome profiles, and pregnancy outcomes were collected and compared. Within the PPROM group, patients were subdivided into an Early Treatment group (received intravenous cefuroxime sodium within 12 hours of membrane rupture, n=120) and a Late Treatment group (received antibiotics after 12 hours, n=120). Statistical analyses were performed using SPSS 22.0.
Results: Genital infections (73.8% vs 20.4%, p< 0.001) and gestational diabetes mellitus (GDM; 53.3% vs 22.9%, p< 0.001) were significantly more prevalent in the PPROM group and were identified as independent risk factors (Genital infections: OR=3.895; GDM: OR=11.166). The PPROM group had worse outcomes, including a higher cesarean section rate (39.2% vs 25.8%, p=0.002) and higher incidences of neonatal asphyxia (4.2% vs 0.4%, p=0.006) and sepsis (2.5% vs 0%, p=0.040). Compared to the Late Treatment group, the Early Treatment group demonstrated significantly lower rates of intrauterine infection (1.67% vs 7.50%, p< 0.05), cesarean section (30.0% vs 48.3%, p< 0.05), neonatal asphyxia (0.83% vs 7.50%, p< 0.01), and neonatal sepsis (0% vs 5.00%, p< 0.05).
Conclusion: Genital tract infections and GDM are significant risk factors for PPROM. Early administration of antibiotics within 12 hours of membrane rupture is associated with substantially improved maternal and neonatal outcomes, underscoring its critical importance in clinical management.
Keywords: preterm premature rupture of membranes, PPROM, genital tract infections, timing of antibiotic treatment, maternal and infant outcomes, chorioamnionitis
Department of Pediatric, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325200, People’s Republic of China
Correspondence: Dehua Zhou, Email qcyx567@163.com
Objective: This study aimed to analyze the risk factors for Preterm Premature Rupture of Membranes (PPROM) and evaluate the impact of the timing of antibiotic administration on maternal and neonatal outcomes.
Methods: A retrospective cohort study was conducted involving 480 pregnant women (240 with PPROM and 240 without PPROM) hospitalized between January 2021 and December 2022. Maternal data, genital microbiome profiles, and pregnancy outcomes were collected and compared. Within the PPROM group, patients were subdivided into an Early Treatment group (received intravenous cefuroxime sodium within 12 hours of membrane rupture, n=120) and a Late Treatment group (received antibiotics after 12 hours, n=120). Statistical analyses were performed using SPSS 22.0.
Results: Genital infections (73.8% vs 20.4%, p< 0.001) and gestational diabetes mellitus (GDM; 53.3% vs 22.9%, p< 0.001) were significantly more prevalent in the PPROM group and were identified as independent risk factors (Genital infections: OR=3.895; GDM: OR=11.166). The PPROM group had worse outcomes, including a higher cesarean section rate (39.2% vs 25.8%, p=0.002) and higher incidences of neonatal asphyxia (4.2% vs 0.4%, p=0.006) and sepsis (2.5% vs 0%, p=0.040). Compared to the Late Treatment group, the Early Treatment group demonstrated significantly lower rates of intrauterine infection (1.67% vs 7.50%, p< 0.05), cesarean section (30.0% vs 48.3%, p< 0.05), neonatal asphyxia (0.83% vs 7.50%, p< 0.01), and neonatal sepsis (0% vs 5.00%, p< 0.05).
Conclusion: Genital tract infections and GDM are significant risk factors for PPROM. Early administration of antibiotics within 12 hours of membrane rupture is associated with substantially improved maternal and neonatal outcomes, underscoring its critical importance in clinical management.
Keywords: preterm premature rupture of membranes, PPROM, genital tract infections, timing of antibiotic treatment, maternal and infant outcomes, chorioamnionitis