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已发表论文
中国浙江东部沿海地区一家三级医院碳青霉烯耐药肺炎克雷伯菌的特征分析：一种新型 ST6853 克隆的检出
Authors Mo Y, Wang J , Zhai M, Lao K, Han J, Zhu M, Weng X
Received 13 September 2025
Accepted for publication 25 December 2025
Published 15 January 2026 Volume 2026:19 564277
DOI https://doi.org/10.2147/IDR.S564277
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hazrat Bilal
Yijun Mo,1,* Jieyi Wang,1,* Min Zhai,2 Kaihang Lao,3 Jiani Han,1 Minhong Zhu,4 Xingbei Weng1
1Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People’s Republic of China; 2Disease Test Laboratory, Ningbo International Travel Healthcare Center, Ningbo, Zhejiang, People’s Republic of China; 3Department of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Laboratory Medicine, Ninghai County Third Hospital, Ningbo, Zhejiang, 315010, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xingbei Weng, Email wxb6006@hotmail.com
Purpose: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is linked to hospital-acquired infections and associated with significant mortality rates, presenting a serious risk to public health. This research aimed to examine the in-hospital epidemiology and antimicrobial resistance of CRKP isolates, offering insights for the management and control of CRKP infections.
Patients and Methods: In total, 76 carbapenem-resistant Klebsiella pneumoniae isolates were collected from inpatients at the First Affiliated Hospital of Ningbo University from May 2022 and February 2024. The isolates were mainly acquired from sputum, urine, secretions, and blood. Antimicrobial susceptibility testing was performed using the VITEK 2 Compact system or the Kirby-Bauer disk-diffusion method. In addition to susceptibility testing, phylogenetic analysis, and serotype analysis, whole genome sequencing was conducted to identify genes associated with antibiotic resistance.
Results: Antimicrobial susceptibility testing showed that all 76 CRKP isolates were resistant to most common antibiotics. The CRKP isolates mainly carried Klebsiella pneumoniae carbapenemase, and the predominant gene was blaKPC-2. Homology analysis found that the major sequence type (ST) was ST11, as a single isolate was identified as an ST11 single-locus variant (ST6853), followed by ST15 and ST48. Serotype analysis found that the major serotype was K64, followed by K24 and K62.
Conclusion: The CRKP isolates in our study exhibited resistance to the majority of commonly used antibiotics. The blaKPC-2 gene was identified as the predominant carbapenemase. The major ST of CRKP found in our hospital was ST11, with K64 and O2a being the prevalent predicted serotypes. These findings should prove useful for the control and management of CRKP infections, and provided guidance for clinical antibiotic therapy.
Keywords: Klebsiella pneumoniae, carbapenem resistant, antimicrobial resistance, bacterial infections, nosocomial infections
1Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People’s Republic of China; 2Disease Test Laboratory, Ningbo International Travel Healthcare Center, Ningbo, Zhejiang, People’s Republic of China; 3Department of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Laboratory Medicine, Ninghai County Third Hospital, Ningbo, Zhejiang, 315010, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xingbei Weng, Email wxb6006@hotmail.com
Purpose: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is linked to hospital-acquired infections and associated with significant mortality rates, presenting a serious risk to public health. This research aimed to examine the in-hospital epidemiology and antimicrobial resistance of CRKP isolates, offering insights for the management and control of CRKP infections.
Patients and Methods: In total, 76 carbapenem-resistant Klebsiella pneumoniae isolates were collected from inpatients at the First Affiliated Hospital of Ningbo University from May 2022 and February 2024. The isolates were mainly acquired from sputum, urine, secretions, and blood. Antimicrobial susceptibility testing was performed using the VITEK 2 Compact system or the Kirby-Bauer disk-diffusion method. In addition to susceptibility testing, phylogenetic analysis, and serotype analysis, whole genome sequencing was conducted to identify genes associated with antibiotic resistance.
Results: Antimicrobial susceptibility testing showed that all 76 CRKP isolates were resistant to most common antibiotics. The CRKP isolates mainly carried Klebsiella pneumoniae carbapenemase, and the predominant gene was blaKPC-2. Homology analysis found that the major sequence type (ST) was ST11, as a single isolate was identified as an ST11 single-locus variant (ST6853), followed by ST15 and ST48. Serotype analysis found that the major serotype was K64, followed by K24 and K62.
Conclusion: The CRKP isolates in our study exhibited resistance to the majority of commonly used antibiotics. The blaKPC-2 gene was identified as the predominant carbapenemase. The major ST of CRKP found in our hospital was ST11, with K64 and O2a being the prevalent predicted serotypes. These findings should prove useful for the control and management of CRKP infections, and provided guidance for clinical antibiotic therapy.
Keywords: Klebsiella pneumoniae, carbapenem resistant, antimicrobial resistance, bacterial infections, nosocomial infections