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已发表论文
针对血睾屏障的纳米试剂：男性生殖系统疾病诊疗策略
Authors Zhang G, Zhao Y, Du X, Li N, Jiang M, Zhi W, Zeng Q, Yan H , Liu J, Zeng J, Miao Y, Liu W
Received 7 August 2025
Accepted for publication 11 December 2025
Published 15 January 2026 Volume 2026:21 559115
DOI https://doi.org/10.2147/IJN.S559115
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sachin Mali
Guohui Zhang,1– 3,* Yuhong Zhao,1– 3,* Xinrong Du,4,* Ningjing Li,4 Min Jiang,4 Weiwei Zhi,5 Qin Zeng,5 Heqiu Yan,6 Jun Liu,4 Jiuzhi Zeng,5 Yangbao Miao,7 Weixin Liu1– 3
1Center of Women’s and Children’s Health Medical Research and Technology Innovation, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 2Key Laboratory of Fertility Preservation and Promotion, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 3Key Laboratory for Minimally Invasive/Non-invasive Diagnosis and Treatment of Female Reproductive System Diseases and Lifelong Reproductive Health Protection, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 4School of Medicine and Life sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China; 5Key Laboratory of Reproductive Medicine, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 6School of Clinical Laboratory Medicine, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 7Department of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine of University of Electronic Science and Technology of China, Chengdu, 610072, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weixin Liu, Email liuweixind@163.com Yangbao Miao, Email miaoyangbao@uestc.edu.cn
Abstract: Male reproductive health represents a critical yet challenging area of medical science, where conventional diagnostics and therapies are often limited by physiological barriers—particularly the blood-testis barrier (BTB)—and the complex etiology of disorders such as infertility, prostate cancer, and erectile dysfunction. In recent years, nanoreagents has emerged as a transformative tool, enabling unprecedented advances in drug delivery, imaging, and therapeutic precision. This review systematically examines the application of diverse nanomaterials—including metal nanoparticles, lipid-based systems, polymeric carriers, and natural derivatives such as nanobodies, extracellular vesicles, and cell membrane-coated nanoparticles—in the context of male reproductive medicine. These platforms facilitate targeted drug delivery across the BTB, enhance local drug bioavailability, minimize systemic toxicity, and support sustained release profiles. In diagnostic imaging, nanotechnology augments modalities such as MRI, PET, and photoacoustic imaging. Furthermore, natural biomaterials offer biocompatible and immunologically inert strategies for drug encapsulation and targeted transport, improving both efficacy and safety. Despite these promising developments, challenges remain in standardization, long-term biosafety, and scalable synthesis. Nevertheless, the integration of nanotechnology in male reproductive health is poised to redefine treatment paradigms, offering personalized, efficient, and minimally invasive solutions. As research progresses, nano-based approaches hold significant potential to address unmet clinical needs and improve reproductive outcomes worldwide.
Keywords: nanoparticle, blood-testis barrier, reproductive system diseases, drug delivery, biomaterials
1Center of Women’s and Children’s Health Medical Research and Technology Innovation, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 2Key Laboratory of Fertility Preservation and Promotion, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 3Key Laboratory for Minimally Invasive/Non-invasive Diagnosis and Treatment of Female Reproductive System Diseases and Lifelong Reproductive Health Protection, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 4School of Medicine and Life sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China; 5Key Laboratory of Reproductive Medicine, Sichuan Provincial Women’s and Children’s Hospital/ The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, 610045, People’s Republic of China; 6School of Clinical Laboratory Medicine, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 7Department of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine of University of Electronic Science and Technology of China, Chengdu, 610072, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weixin Liu, Email liuweixind@163.com Yangbao Miao, Email miaoyangbao@uestc.edu.cn
Abstract: Male reproductive health represents a critical yet challenging area of medical science, where conventional diagnostics and therapies are often limited by physiological barriers—particularly the blood-testis barrier (BTB)—and the complex etiology of disorders such as infertility, prostate cancer, and erectile dysfunction. In recent years, nanoreagents has emerged as a transformative tool, enabling unprecedented advances in drug delivery, imaging, and therapeutic precision. This review systematically examines the application of diverse nanomaterials—including metal nanoparticles, lipid-based systems, polymeric carriers, and natural derivatives such as nanobodies, extracellular vesicles, and cell membrane-coated nanoparticles—in the context of male reproductive medicine. These platforms facilitate targeted drug delivery across the BTB, enhance local drug bioavailability, minimize systemic toxicity, and support sustained release profiles. In diagnostic imaging, nanotechnology augments modalities such as MRI, PET, and photoacoustic imaging. Furthermore, natural biomaterials offer biocompatible and immunologically inert strategies for drug encapsulation and targeted transport, improving both efficacy and safety. Despite these promising developments, challenges remain in standardization, long-term biosafety, and scalable synthesis. Nevertheless, the integration of nanotechnology in male reproductive health is poised to redefine treatment paradigms, offering personalized, efficient, and minimally invasive solutions. As research progresses, nano-based approaches hold significant potential to address unmet clinical needs and improve reproductive outcomes worldwide.
Keywords: nanoparticle, blood-testis barrier, reproductive system diseases, drug delivery, biomaterials