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已发表论文
通过混合膜包覆仿生脂质体靶向共递送姜黄素和黄芪甲苷 IV 以增强肺癌治疗效果
Authors Liu H, Lv L, Yang S, Peng M, Tu K, Wu Y, Cai L
Received 4 August 2025
Accepted for publication 22 December 2025
Published 14 January 2026 Volume 2026:21 558285
DOI https://doi.org/10.2147/IJN.S558285
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Dong Wang
Hongmei Liu,1,* Liangliang Lv,1,2,* Shangqin Yang,1,* Mingjie Peng,1,3 Kerong Tu,1 Yanheng Wu,1 Lulu Cai1
1Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 2Department of Pharmacy, Yuechi County People’s Hospital, Guangan, People’s Republic of China; 3School of Pharmacy, Chengdu University, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lulu Cai, Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, People’s Republic of China, Email cailulu@med.uestc.edu.cn
Background: Lung cancer is the malignant tumor with the highest incidence and lethality worldwide. Existing therapeutic modalities suffer from side effects, drug resistance, and limited efficacy, and there is an urgent need to develop safer and more effective therapeutic strategies. Curcumin (Cur) and astragaloside IV (AS) are promising natural anti-cancer agents. However, their poor aqueous solubility and low bioavailability limit their clinical efficacy. Natural cell membrane-based biomimetic drug delivery platform provides an effective strategy for efficient and targeted co-administration.
Methods: The optimal synergistic ratio of Cur and AS against lung cancer cells was determined using the Combination Index (CI) method. Dual-drug-loaded liposomes were prepared via the thin-film hydration method and subsequently coated with a hybrid membrane derived from cancer cells and erythrocytes to form biomimetic liposomes (CM@AC lip). These nanoparticles were characterized for size, charge, stability, and drug release. Their targeting, endocytosis mechanism, antitumor efficacy, and biosafety were evaluated in vitro and in vivo.
Results: The CM@AC liposomes exhibited a uniform spherical structure with a synergistic ratio of 1.5:1 for AS and Cur. The liposomes had a particle size of 111.86 ± 4.12 nm, a Zeta potential of − 20.8 ± 3.63 mV, and encapsulation efficiencies of 63.81 ± 1.22% for Cur and 60.38 ± 0.89% for AS, respectively. The liposomes demonstrated excellent stability. Cellular and animal studies confirmed its superior tumor-targeting ability and immune evasion. CM@AC lip significantly enhanced cytotoxicity, apoptosis, and invasion inhibition against Lewis lung carcinoma cells compared to single-drug treatments. In vivo, it achieved a high tumor inhibition rate (74.59 ± 17.52%) without inducing significant systemic toxicity.
Conclusion: The hybrid membrane-coated biomimetic liposome effectively co-delivers Cur and AS-IV, demonstrating enhanced antitumor efficacy and favorable biosafety via synergistic action, improved targeting, and immune evasion. This strategy presents a promising platform for lung cancer combination therapy.
Keywords: lung cancer, curcumin, astragaloside IV, biomimetic liposomes, targeted delivery
1Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China; 2Department of Pharmacy, Yuechi County People’s Hospital, Guangan, People’s Republic of China; 3School of Pharmacy, Chengdu University, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lulu Cai, Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, People’s Republic of China, Email cailulu@med.uestc.edu.cn
Background: Lung cancer is the malignant tumor with the highest incidence and lethality worldwide. Existing therapeutic modalities suffer from side effects, drug resistance, and limited efficacy, and there is an urgent need to develop safer and more effective therapeutic strategies. Curcumin (Cur) and astragaloside IV (AS) are promising natural anti-cancer agents. However, their poor aqueous solubility and low bioavailability limit their clinical efficacy. Natural cell membrane-based biomimetic drug delivery platform provides an effective strategy for efficient and targeted co-administration.
Methods: The optimal synergistic ratio of Cur and AS against lung cancer cells was determined using the Combination Index (CI) method. Dual-drug-loaded liposomes were prepared via the thin-film hydration method and subsequently coated with a hybrid membrane derived from cancer cells and erythrocytes to form biomimetic liposomes (CM@AC lip). These nanoparticles were characterized for size, charge, stability, and drug release. Their targeting, endocytosis mechanism, antitumor efficacy, and biosafety were evaluated in vitro and in vivo.
Results: The CM@AC liposomes exhibited a uniform spherical structure with a synergistic ratio of 1.5:1 for AS and Cur. The liposomes had a particle size of 111.86 ± 4.12 nm, a Zeta potential of − 20.8 ± 3.63 mV, and encapsulation efficiencies of 63.81 ± 1.22% for Cur and 60.38 ± 0.89% for AS, respectively. The liposomes demonstrated excellent stability. Cellular and animal studies confirmed its superior tumor-targeting ability and immune evasion. CM@AC lip significantly enhanced cytotoxicity, apoptosis, and invasion inhibition against Lewis lung carcinoma cells compared to single-drug treatments. In vivo, it achieved a high tumor inhibition rate (74.59 ± 17.52%) without inducing significant systemic toxicity.
Conclusion: The hybrid membrane-coated biomimetic liposome effectively co-delivers Cur and AS-IV, demonstrating enhanced antitumor efficacy and favorable biosafety via synergistic action, improved targeting, and immune evasion. This strategy presents a promising platform for lung cancer combination therapy.
Keywords: lung cancer, curcumin, astragaloside IV, biomimetic liposomes, targeted delivery