115563
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
急性早幼粒细胞白血病诱导治疗期间的渗出性视网膜脱离：分化综合征的一种表现
Authors Zheng X , Zhang X, Yu H, Zang S
Received 6 August 2025
Accepted for publication 30 December 2025
Published 14 January 2026 Volume 2026:19 558934
DOI https://doi.org/10.2147/IMCRJ.S558934
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Xudong Zhu
Xianqi Zheng,1,2 Xiayin Zhang,1,3 Honghua Yu,1,4 Siwen Zang1,5
1Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China; 2Guangzhou Aier Eye Hospital, Jinan University, Guangzhou, People’s Republic of China; 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; 4Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 5Department of Ophthalmology, Guangdong Provincial People’s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People’s Republic of China
Correspondence: Siwen Zang, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Second Road, Yuexiu District, Guangzhou, People’s Republic of China, Tel +86 13925198097, Email zangsiwen@gdph.org.cn
Background/Aim: This report describes a case of exudative retinal detachment as an ocular manifestation of differentiation syndrome (DS) during induction therapy for acute promyelocytic leukemia (APL). A concise review of the literatures is also provided.
Case Presentation: A 25-year-old female with APL received induction therapy with all-trans retinoic acid (ATRA), arsenic trioxide (ATO), and daunorubicin. On day 15 of induction therapy, she developed dyspnea with pulmonary infiltrates, alongside bilateral epiphora and blurred vision in her right eye. Ophthalmic examination revealed a best-corrected visual acuity (BCVA) of 20/40 in the right eye and 20/20 in the left. Fundus examination demonstrated macular edema, mild optic disc edema, undulating exudative retinal detachment in the posterior pole and mid-peripheral retina, and scattered superficial hemorrhages bilaterally. Optical coherence tomography demonstrated corrugated retinal pigment epithelium elevation with subretinal fluid (SRF), choroidal thickening in both eyes, and neurosensory epithelium detachment in the right macula. Fundus fluorescein angiography confirmed diffuse vascular leakage bilaterally. A diagnosis of DS was established. Management with systemic corticosteroids, ATRA dose reduction, and ATO discontinuation led to the complete resolution of SRF and restoration of BCVA to 20/20 in both eyes within one month.
Conclusion: Exudative retinal detachment can be an ocular manifestation of DS during APL induction therapy, likely attributable to systemic capillary leakage. Prompt intervention with systemic corticosteroids is effective and generally associated with a favorable visual prognosis.
Keywords: exudative retinal detachment, differentiation syndrome, acute promyelocytic leukemia, all-trans retinoic acid, arsenic trioxide
1Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China; 2Guangzhou Aier Eye Hospital, Jinan University, Guangzhou, People’s Republic of China; 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; 4Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 5Department of Ophthalmology, Guangdong Provincial People’s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou, People’s Republic of China
Correspondence: Siwen Zang, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Second Road, Yuexiu District, Guangzhou, People’s Republic of China, Tel +86 13925198097, Email zangsiwen@gdph.org.cn
Background/Aim: This report describes a case of exudative retinal detachment as an ocular manifestation of differentiation syndrome (DS) during induction therapy for acute promyelocytic leukemia (APL). A concise review of the literatures is also provided.
Case Presentation: A 25-year-old female with APL received induction therapy with all-trans retinoic acid (ATRA), arsenic trioxide (ATO), and daunorubicin. On day 15 of induction therapy, she developed dyspnea with pulmonary infiltrates, alongside bilateral epiphora and blurred vision in her right eye. Ophthalmic examination revealed a best-corrected visual acuity (BCVA) of 20/40 in the right eye and 20/20 in the left. Fundus examination demonstrated macular edema, mild optic disc edema, undulating exudative retinal detachment in the posterior pole and mid-peripheral retina, and scattered superficial hemorrhages bilaterally. Optical coherence tomography demonstrated corrugated retinal pigment epithelium elevation with subretinal fluid (SRF), choroidal thickening in both eyes, and neurosensory epithelium detachment in the right macula. Fundus fluorescein angiography confirmed diffuse vascular leakage bilaterally. A diagnosis of DS was established. Management with systemic corticosteroids, ATRA dose reduction, and ATO discontinuation led to the complete resolution of SRF and restoration of BCVA to 20/20 in both eyes within one month.
Conclusion: Exudative retinal detachment can be an ocular manifestation of DS during APL induction therapy, likely attributable to systemic capillary leakage. Prompt intervention with systemic corticosteroids is effective and generally associated with a favorable visual prognosis.
Keywords: exudative retinal detachment, differentiation syndrome, acute promyelocytic leukemia, all-trans retinoic acid, arsenic trioxide