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已发表论文

利用酸诱导二氧化硅纳米颗粒释放多柔比星 (Doxorubicin) 进行甲状腺癌的靶向治疗

 

Authors Li SJ, Zhang DQ, Sheng SH, Sun H

Received 17 March 2017

Accepted for publication 7 June 2017

Published 21 August 2017 Volume 2017:12 Pages 5993—6003

DOI https://doi.org/10.2147/IJN.S137335

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun

Abstract: Currently, therapy for thyroid cancer mainly involves surgery and radioiodine therapy. However, chemotherapy can be used in advanced and aggressive thyroid cancer that cannot be treated by other options. Nevertheless, a major obstacle to the successful treatment of thyroid cancer is the delivery of drugs to the thyroid gland. Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid–stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer. Doxorubicin nanoparticles can be triggered by acid to release the drug payload for cancer therapy. These nanoparticles shrink the tumor size in vivo with less toxic side effects. This research paves the way toward effective chemotherapy for thyroid cancer.
Keywords: thyroid cancer, silicon dioxide nanoparticle, doxorubicin, acid-triggered release




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