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已发表论文
肝细胞癌中肿瘤免疫微环境和外周血炎症细胞的预后价值
Received 16 December 2025
Accepted for publication 10 April 2026
Published 20 April 2026 Volume 2026:13 587532
DOI https://doi.org/10.2147/JHC.S587532
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Ali Hosni
Lin Sun,1,* Zhensheng Yue,1,2,* Lin Wang1
1Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 2Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lin Wang, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China, Tel +86-29-84775933, Fax +86-29-83246270, Email 1749771520@qq.com
Background: The tumor immune microenvironment and ratios of peripheral blood inflammatory factors have been associated with prognosis in various malignancies. While they show prognostic potential in some cancers, their value in hepatocellular carcinoma (HCC) remains unclear.
Methods: We analyzed 371 HCC patients from The Cancer Genome Atlas (TCGA) and a retrospective cohort from Xijing Hospital. Optimal cut-off values for the lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and platelet-to-lymphocyte ratio (PLR) were determined using ROC curve analysis. Associations with clinicopathological features and disease-free survival (DFS) were assessed using Kaplan-Meier and Cox regression analyses.
Results: Kaplan-Meier analysis showed that high CD8+ T cell and NK cell infiltration were associated with favorable outcomes. Univariate analysis identified low PNI (≤ 41.6), low LMR (≤ 2.38), high PLR (> 88.64), age, and lymph node metastasis as significant risk factors for DFS. Multivariate Cox analysis established low PNI, high PLR, and lymph node metastasis as independent prognostic factors.
Conclusion: High intratumoral CD8+ T cell and natural killer cell (NK cell) levels correlate with better survival. Preoperative PNI, PLR, and lymph node status are independent prognostic indicators for HCC patients.
Keywords: peripheral blood inflammatory markers, clinicopathological features, hepatocellular carcinoma, prognosis
1Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 2Department of Ophthalmology, Xi-Jing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lin Wang, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China, Tel +86-29-84775933, Fax +86-29-83246270, Email 1749771520@qq.com
Background: The tumor immune microenvironment and ratios of peripheral blood inflammatory factors have been associated with prognosis in various malignancies. While they show prognostic potential in some cancers, their value in hepatocellular carcinoma (HCC) remains unclear.
Methods: We analyzed 371 HCC patients from The Cancer Genome Atlas (TCGA) and a retrospective cohort from Xijing Hospital. Optimal cut-off values for the lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and platelet-to-lymphocyte ratio (PLR) were determined using ROC curve analysis. Associations with clinicopathological features and disease-free survival (DFS) were assessed using Kaplan-Meier and Cox regression analyses.
Results: Kaplan-Meier analysis showed that high CD8+ T cell and NK cell infiltration were associated with favorable outcomes. Univariate analysis identified low PNI (≤ 41.6), low LMR (≤ 2.38), high PLR (> 88.64), age, and lymph node metastasis as significant risk factors for DFS. Multivariate Cox analysis established low PNI, high PLR, and lymph node metastasis as independent prognostic factors.
Conclusion: High intratumoral CD8+ T cell and natural killer cell (NK cell) levels correlate with better survival. Preoperative PNI, PLR, and lymph node status are independent prognostic indicators for HCC patients.
Keywords: peripheral blood inflammatory markers, clinicopathological features, hepatocellular carcinoma, prognosis