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已发表论文
氧化还原酶样纳米酶：从生物传感到疾病治疗中的分子机制
Authors Cao M, Ma J, Yang Y, Cheng M, Liu J, Pan Z, Du Z
Received 19 December 2025
Accepted for publication 20 March 2026
Published 21 April 2026 Volume 2026:21 590337
DOI https://doi.org/10.2147/IJN.S590337
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr RDK Misra
Mao Cao,1 Jiazi Ma,1 Yong Yang,1 Mengjie Cheng,1 Jianwei Liu,2 Zhifeng Pan,1 Zhongjun Du1,3
1Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, 250062, People’s Republic of China; 2Public Health Monitoring and Evaluation Institute, Shandong Provincial Center for Disease Control and Prevention, Ji’nan, Shandong, 250000, People’s Republic of China; 3Occupational Disease Department, Harbin Second Hospital, Harbin, Heilongjiang Province, 150026, People’s Republic of China
Correspondence: Zhongjun Du, Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877 Jingshi Road, Lixia District, Jinan, Shandong, 250062, People’s Republic of China, Email duzhongjun@sdfmu.edu.cn; duzj1981@163.com; Zhifeng Pan, Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877 Jingshi Road, Lixia District, Jinan, Shandong, 250062, People’s Republic of China, Email 18653199172@163.com
Abstract: Nanozymes, a class of nanomaterials capable of mimicking the functions of natural enzymes, have garnered significant attention in biomedical fields because of their stable catalytic activity, high efficiency, low cost, and tunable enzyme-like properties. In recent years, advances in nanotechnology have led to the development of numerous nanozymes with redoxase-like activities, which have been widely applied in biosensing and disease treatment, demonstrating considerable potential. In this review, we first summarize the redoxase-like activity of nanozymes. From the perspective of redox regulation, we discuss the catalytic mechanisms of nanozymes in biosensing applications, elaborate on the molecular mechanisms involved in tumor therapy, including the induction of apoptosis and ferroptosis, and examine their catalytic pathways in antibacterial and anti-inflammatory treatments. Finally, we also discuss the current limitations and future challenges of nanozymes in biomedical applications, aiming to provide insights for the rational design and clinical translation of next-generation nanozyme-based platforms. This review focuses on the biomedical applications of nanozymes with redoxase-like activity, such as biomolecular sensing, tumor treatment, and antibacterial and anti-inflammatory therapy. (by Figdraw) The diagram illustrates the role of nanoyzmes in various processes. In the center, nanoyzmes are shown with arrows indicating their function in oxidative stress and ROS scavenging. The top section shows oxidative stress with ROS increase, involving OXD and POD. The bottom section shows ROS decrease, involving SOD and CAT. The left side depicts antibacterial and anti-inflammatory effects, with O subscript 2 and O subscript 2 superscript -. The right side shows tumor treatment with apoptosis and ferroptosis, involving H subscript 2 O subscript 2 and OH. The bottom right illustrates biomolecular detection with test tubes. Labels include antibacterial, anti-inflammatory, oxidative stress, tumor treatment, ROS scavenging and biomolecular detection.Diagram of nanoyzmes in antibacterial, anti-inflammatory, oxidative stress, tumor treatment and biomolecular detection.
Keywords: nanozymes, redoxase-like, biosensing, tumor treatment, antibacterial
1Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, 250062, People’s Republic of China; 2Public Health Monitoring and Evaluation Institute, Shandong Provincial Center for Disease Control and Prevention, Ji’nan, Shandong, 250000, People’s Republic of China; 3Occupational Disease Department, Harbin Second Hospital, Harbin, Heilongjiang Province, 150026, People’s Republic of China
Correspondence: Zhongjun Du, Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877 Jingshi Road, Lixia District, Jinan, Shandong, 250062, People’s Republic of China, Email duzhongjun@sdfmu.edu.cn; duzj1981@163.com; Zhifeng Pan, Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 18877 Jingshi Road, Lixia District, Jinan, Shandong, 250062, People’s Republic of China, Email 18653199172@163.com
Abstract: Nanozymes, a class of nanomaterials capable of mimicking the functions of natural enzymes, have garnered significant attention in biomedical fields because of their stable catalytic activity, high efficiency, low cost, and tunable enzyme-like properties. In recent years, advances in nanotechnology have led to the development of numerous nanozymes with redoxase-like activities, which have been widely applied in biosensing and disease treatment, demonstrating considerable potential. In this review, we first summarize the redoxase-like activity of nanozymes. From the perspective of redox regulation, we discuss the catalytic mechanisms of nanozymes in biosensing applications, elaborate on the molecular mechanisms involved in tumor therapy, including the induction of apoptosis and ferroptosis, and examine their catalytic pathways in antibacterial and anti-inflammatory treatments. Finally, we also discuss the current limitations and future challenges of nanozymes in biomedical applications, aiming to provide insights for the rational design and clinical translation of next-generation nanozyme-based platforms. This review focuses on the biomedical applications of nanozymes with redoxase-like activity, such as biomolecular sensing, tumor treatment, and antibacterial and anti-inflammatory therapy. (by Figdraw) The diagram illustrates the role of nanoyzmes in various processes. In the center, nanoyzmes are shown with arrows indicating their function in oxidative stress and ROS scavenging. The top section shows oxidative stress with ROS increase, involving OXD and POD. The bottom section shows ROS decrease, involving SOD and CAT. The left side depicts antibacterial and anti-inflammatory effects, with O subscript 2 and O subscript 2 superscript -. The right side shows tumor treatment with apoptosis and ferroptosis, involving H subscript 2 O subscript 2 and OH. The bottom right illustrates biomolecular detection with test tubes. Labels include antibacterial, anti-inflammatory, oxidative stress, tumor treatment, ROS scavenging and biomolecular detection.Diagram of nanoyzmes in antibacterial, anti-inflammatory, oxidative stress, tumor treatment and biomolecular detection.
Keywords: nanozymes, redoxase-like, biosensing, tumor treatment, antibacterial