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已发表论文
体外和体内蛋白质释放和抗缺血/负载骨形态生成蛋白-2 的甘草次酸 - 聚（乙二醇）-b-聚（L-赖氨酸）纳米颗粒的再灌注损伤特性
Authors Shan F, Liu Y, Jiang H, Tong F
Received 16 July 2017
Accepted for publication 17 September 2017
Published 17 October 2017 Volume 2017:12 Pages 7613—7625
DOI https://doi.org/10.2147/IJN.S146546
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Linlin Sun
Abstract: Here, we
describe a bone morphogenetic protein-2 (BMP-2) nanocarrier based on
glycyrrhetinic acid (GA)-poly(ethylene glycol) (PEG)-b-poly(L-lysine) (PLL). A
protein nanocarrier was synthesized, characterized and evaluated as a BMP-2
delivery system. The designed nanocarrier was synthesized based on the
ring-opening polymerization of amino acid N-carboxyanhydride. The final product
was measured with 1H nuclear
magnetic resonance. GA-PEG-b-PLL nanocarrier could combine with BMP-2 through
electrostatic interaction to form polyion complex (PIC) micelles. BMP-2 could
be rapidly and efficiently encapsulated through the GA-PEG-b-PLL nanocarrier
under physiological conditions, exhibiting efficient encapsulation and
sustained release. In addition, the GA-PEG-b-PLL-mediated BMP-2 delivery system
could target the liver against hepatic diseases as it has GA-binding receptors.
The anti-hepatic ischemia/reperfusion injury (anti-HI/RI) effect of
BMP-2/GA-PEG-b-PLL PIC micelles was investigated in rats using free BMP-2 and BMP-2/PEG-b-PLL
PIC micelles as controls, and the results showed that BMP-2/GA-PEG-b-PLL PIC
micelles indicated significantly enhanced anti-HI/RI property compared to BMP-2
and BMP-2/PEG-b-PLL. All results suggested that GA-PEG-b-PLL could be used as a
potential BMP-2 nanocarrier.
Keywords: GA-PEG-b-PLL, PIC micelles, BMP-2, HI/RI
Keywords: GA-PEG-b-PLL, PIC micelles, BMP-2, HI/RI
