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已发表论文
CMTM4 表达对肝细胞癌的临床意义
Authors Bei CH, Zhang Y, Wei RM, Zhu XN, Wang ZG, Zeng W, Chen QY, Tan SK
Received 25 August 2017
Accepted for publication 4 October 2017
Published 14 November 2017 Volume 2017:10 Pages 5439—5443
DOI https://doi.org/10.2147/OTT.S149786
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 3
Editor who approved publication: Dr Tohru Yamada
Abstract: CMTM4 is the
most conserved member of chemokine-like factor (CKLF)-like MARVEL transmembrane
domain-containing (CMTM) family on chromosome 16q22.1, a locus that harbors a
number of tumor-suppressor genes. In previous studies, CMTM4 was reported to be
downregulated and exhibited tumor-suppressor activities by regulating cell
growth and cell cycle in clear cell renal cell carcinoma. However, its roles in
tumorigenesis of hepatocellular carcinoma (HCC) remain poorly studied. This
study first investigated the expression of CMTM4 in HCC, and then examined the
association between the expression of CMTM4 with the clinicopathological features
and prognosis of HCC patients. It was found that CMTM4 was downregulated in HCC
tissues, compared with matched adjacent nontumor tissues, as detected by
immunohistochemistry. In addition, Kaplan–Meier survival analysis showed that
the negative expression of CMTM4 was associated with decreased overall survival
rates in patients with HCC. The results of this study suggest CMTM4 plays a
role as a tumor suppressor in HCC and CMTM4 negative expression is a risk
factor for poor prognosis of HCC.
Keywords: chemokine-like factor-like MARVEL transmembrane domain-containing 4, hepatocellular carcinoma, immunohistochemistry, prognosis
Keywords: chemokine-like factor-like MARVEL transmembrane domain-containing 4, hepatocellular carcinoma, immunohistochemistry, prognosis
