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已发表论文
利用网络药理学方法确定草药治疗风湿性关节炎的协同机制
Authors Xu XX, Bi JP, Ping L, Li P, Li F
Received 8 January 2018
Accepted for publication 12 March 2018
Published 24 April 2018 Volume 2018:12 Pages 967—979
DOI https://doi.org/10.2147/DDDT.S161904
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Palas Chanda
Peer reviewer comments 2
Editor who approved publication: Dr Qiongyu Guo
Purpose: The purpose of
this study was to investigate the therapeutic mechanism(s) of Clematis chinensis Osbeck/Notopterygium incisum K.C.
Ting ex H.T (CN).
Methods: A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used.
Results: This approach successfully helped to identify 12 active ingredients of CN, interacting with 13 key targets (Akt1, STAT3, TNFsf13, TP53, EPHB2, IL-10, IL-6, TNF, MAPK8, IL-8, RELA, ROS1 and STAT4). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that CN-regulated pathways were mainly classified into signal transduction and immune system.
Conclusion: The present work may help to illustrate the mechanism(s) of action of CN, and it may provide a better understanding of antirheumatic effects.
Keywords: targets prediction, pathways analysis, action mechanism, Clematis chinensis Osbeck, Notopterygium incisum K.C. Ting ex H.T. Chang
Methods: A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used.
Results: This approach successfully helped to identify 12 active ingredients of CN, interacting with 13 key targets (Akt1, STAT3, TNFsf13, TP53, EPHB2, IL-10, IL-6, TNF, MAPK8, IL-8, RELA, ROS1 and STAT4). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that CN-regulated pathways were mainly classified into signal transduction and immune system.
Conclusion: The present work may help to illustrate the mechanism(s) of action of CN, and it may provide a better understanding of antirheumatic effects.
Keywords: targets prediction, pathways analysis, action mechanism, Clematis chinensis Osbeck, Notopterygium incisum K.C. Ting ex H.T. Chang
