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脂质运载蛋白 2: 乳腺癌转移的潜在靶标
Authors Hu C, Yang K, Li M, Huang W, Zhang F, Wang H
Received 24 July 2018
Accepted for publication 17 October 2018
Published 13 November 2018 Volume 2018:11 Pages 8099—8106
DOI https://doi.org/10.2147/OTT.S181223
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr William Cho
摘要：尽管针对乳腺癌系统疗法减少癌症相关死亡率，但转移性乳腺癌仍然能够逃避各种治疗，尤其是三阴性乳腺癌，转移率高，临床预后差。脂质运载蛋白 2（lipocalin 2，LCN2）是一种分泌型糖蛋白可运输小分子亲脂性配体。LCN2 异常表达在乳腺癌上皮-间质转化、血管生成、细胞侵袭和迁移中发挥重要作用，尤其能够介导多种信号途径促进癌症的发生和转移。本文就 LCN2 异常表达对乳腺癌的进展作一总结，并重点阐述乳腺癌侵袭转移过程中 LCN2 作为潜在靶标及其相关分子机制的最新进展。
关键词：脂质运载蛋白 2；乳腺癌；转移；三阴性乳腺癌；上皮-间质转化；血管生成
