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臂丛神经撕脱伤后神经病理性疼痛模型及诱发的脊髓胶质细胞激活
Authors Hou AL, Xu WD
Received 19 May 2018
Accepted for publication 23 August 2018
Published 13 December 2018 Volume 2018:11 Pages 3171—3179
DOI https://doi.org/10.2147/JPR.S174663
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Michael Ueberall
背景：神经病理性疼痛是臂丛神经损伤后常见且棘手的并发症。
材料和方法：为了研究臂丛神经损伤后神经病理性疼痛的潜在机制，我们改良了臂丛神经撕脱方法，从而建立了神经病理性疼痛的大鼠模型。
结果：行为学观测结果表明实验组大鼠术后均出现神经病理性疼痛，双侧后肢机械痛阈明显下降。实验组大鼠颈段脊髓背角双侧 GFAP 表达在术后 1 天时出现增强，4 天时明显增强。而损伤侧 IBA-1 表达在术后 1 天时出现增强，持续至术后 28 天。
结论：该改良的臂丛撕脱伤模型可以模拟神经病理性疼痛的发生和发展过程。脊髓内星形胶质细胞和小胶质细胞的激活在神经病理性疼痛的机制和治疗中发挥重要作用。
Keywords: neuropathic
pain, new model, astrocyte, microglia
