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负载阿霉素-氯霉素 E6 的介孔二氧化硅纳米粒子与超声相结合对三阴性乳腺癌的治疗效果
Authors Xu P, Yao J, Li Z, Wang M, Zhou L, Zhong G, Zheng Y, Li N, Zhai Z, Yang S, Wu Y, Zhang D, Dai Z
Received 19 December 2019
Accepted for publication 6 April 2020
Published 21 April 2020 Volume 2020:15 Pages 2659—2668
DOI https://doi.org/10.2147/IJN.S243037
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Mian Wang
Introduction: Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed to enhance its efficiency and overcome the side effects of chemotherapy.
Materials and Methods: In this study, we synthesized and characterized mesoporous silica nanoparticles (MSN-DOX-Ce6) loaded with doxorubicin (DOX) and sonosensitizer, chlorin e6 (Ce6). Then, we conducted in vitro and in vivo experiments to explore the antitumor effect of MSN-DOX-Ce6 under ultrasound (US) treatment.
Results: The characterization tests showed that the nanoparticles are uniformly sized spheres with mesoporous structure, resulting in a high drug-loading efficiency. In the in vitro experiments, MSN-DOX-Ce6 could effectively inhibit cell proliferation under US but not more than other treatment groups. However, the in vivo studies showed that MSN-DOX-Ce6+US has better antitumor effect than DOX+Ce6+US or DOX alone on xenograft tumor-bearing mice.
Conclusion: In summary, MSNs showed a great potential for DOX and Ce6 delivery. We concluded that under US, MSN-DOX-Ce6 nanocomposites increase the antitumor effect of DOX and SDT and thereby are a potential treatment for solid tumors.
Keywords: sonodynamic therapy, co-delivery, combination chemotherapy, nanomaterials