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线粒体靶向、氧充足的全氟化碳纳米粒子用于影像引导的肿瘤光疗
Authors Chen S, Huang B, Pei W, Wang L, Xu Y, Niu C
Received 12 September 2020
Accepted for publication 13 October 2020
Published 5 November 2020 Volume 2020:15 Pages 8641—8658
DOI https://doi.org/10.2147/IJN.S281649
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Yan Shen
Background: Although photothermal therapy (PTT) and photodynamics therapy (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to the limitations of the penetration depth in PTT and the hypoxic microenvironment of tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment.
Methods and Materials: In this work, a mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed for the synergistic PDT/photothermal therapy (PTT) of cancer through image guiding.
Results: Importantly, these nanoparticles (NPs) can effectively and accurately accumulate in the target tumor via the enhanced permeability and retention (EPR) effect.
Conclusion: This approach offers a novel technique to achieve outstanding antitumor efficacy by an unprecedented design with tumor mitochondria targeting, oxygen delivery, and synergistic PDT/PTT with dual-imaging guidance.
Keywords: IR780, mitochondria-targeting, perfluorocarbon, photodynamic therapy, photothermal therapy