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外显体在食管癌发病机制、诊断和治疗中的意义
Authors Jing Z , Chen K, Gong L
Received 14 June 2021
Accepted for publication 16 August 2021
Published 3 September 2021 Volume 2021:16 Pages 6115—6127
DOI https://doi.org/10.2147/IJN.S321555
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Yan Shen
Abstract: Esophageal cancer is one of the most common malignancy in China with high mortality. Understanding pathogenesis and identifying early diagnosis biomarkers can significantly improve the prognosis of patients with esophageal cancer. Exosomes are small vesicular structures containing a variety of components (including DNA, RNA, and proteins) mediating cell-to-cell material exchange and signal communication. Growing evidences have shown that exosomes and its components are involved in growth, metastasis and angiogenesis in cancer, and could also be used as diagnostic and prognostic markers. In this review, we summarized recent progress to elucidate the significance of exosomes in the esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression. We also discuss the utility of exosomes as diagnostic and prognostic biomarkers and therapeutic tool in esophageal cancer.
Keywords: exosome, esophageal cancer, biomarkers, liquid biopsy, prognosis