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HRCT 对肺 MALT 淋巴瘤肺炎样实变型与大叶性肺炎鉴别诊断的评价
Authors Qiu W, Chen H, Zhang J, Shuai R, Zhang H, Guo K, Zhu L, Wang Z
Received 13 July 2021
Accepted for publication 4 October 2021
Published 12 October 2021 Volume 2021:13 Pages 7813—7821
DOI https://doi.org/10.2147/CMAR.S327846
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr A. Emre Eşkazan
Purpose: To assess the performance of high-resolution computed tomography (HRCT) in discriminating the consolidation pattern of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma from lobar pneumonia.
Patients and Methods: This retrospective study comprised 26 patients with pathologically confirmed consolidation pattern of pulmonary MALT lymphoma (12 men and 14 women; mean age, 59.4± 12.1 years) and 36 patients with lobar pneumonia confirmed by body fluids or respiratory secretion culture (16 men and 20 women; mean age, 41.8± 26.3 years). Two radiologists independently evaluated the CT images. The effectiveness of these variables in distinguishing lobar pneumonia from MALT lymphoma was analyzed using logistic regression analysis.
Results: The average age of lobar pneumonia patients was younger than that of MALT lymphoma patients (p =0.002). The respiratory symptom was more common in lobar pneumonia than MALT lymphoma (p =0.002). Signs of bronchiectasis within the consolidation and bulging of interlobar fissure occurred significantly more often in MALT lymphoma than pneumonia (69.2% vs 11.1%, p < 0.0001; 46.2% vs 19.4%, p =0.024). We used the predictors with p < 0.05 (age, respiratory symptoms, bronchiectasis, and bulging of interlobar fissure) to construct a logistic regression model. The area under curve (AUC), negative predictive value (NPV), positive predictive value (PPV), sensitivity, specificity, and accuracy were 0.891, 84.21%, 83.33%, 88.89%, 76.92%, and 83.87% for discriminating lobar pneumonia from MALT lymphoma.
Conclusion: Middle-aged, presence of mild clinical symptoms, bronchiectasis and bulging of the interlobar fissure on chest CT images are potential markers to distinguish pulmonary MALT lymphoma from lobar pneumonia.
Keywords: high-resolution computed tomography, pulmonary mucosa-associated lymphoid tissue lymphoma, lobar pneumonia, diagnosis