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纳米医学:一种新兴的出血性中风治疗策略
Authors Xu Y , Chen A, Wu J, Wan Y, You M, Gu X, Guo H, Tan S, He Q, Hu B
Received 8 January 2022
Accepted for publication 11 April 2022
Published 2 May 2022 Volume 2022:17 Pages 1927—1950
DOI https://doi.org/10.2147/IJN.S357598
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Anderson Oliveira Lobo
Abstract: Hemorrhagic stroke is one of the most devastating diseases worldwide due to a high rate of disability and mortality with few effective treatments. Recent advances in nanomedicines to promote hemostasis, drug delivery, neuroprotection, and nerve regeneration may provide insight into hemorrhagic stroke treatment. In this review, we first view the pathophysiology and conventional therapeutics of hemorrhagic stroke. Second, we comprehensively summarize the current nanomedicines applied in hemorrhagic stroke, including inorganic nanomaterials, polymer-based nanomaterials, lipid-based nanomaterials, self-assembling peptide-based hydrogel, exosomes, and gel systems. Finally, the challenges, opportunities, and future perspectives of nanomedicines for hemorrhagic stroke are discussed. Thus, this review promotes greater exploration of effective therapies for hemorrhagic stroke with nanomedicines.
Keywords: hemorrhagic stroke, nanomedicine, therapy, subarachnoid hemorrhage, intracerebral hemorrhage